TGFBR2 is recruited to tight junctions after TGF-beta stimulation

Stable Identifier
R-HSA-2134519
Type
Reaction [dissociation]
Species
Homo sapiens
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After TGF-beta stimulation, TGFBR2 binds TGFBR1 anchored to tight junctions through association with PARD6A (Ozdamar et al. 2005). FKBP1A (FKBP12) prevents phosphorylation of TGFBR1 by TGFBR2 in the absence of ligand. FKBP1A dissociates from TGFBR1 after it forms a complex with ligand-activated TGFBR2 (Chen et al. 1997). This was inferred from experiments in which a recombinant mouse Pard6a and recombinant human TGFBR1 and TGFBR2 were studied in the context of endogenous mouse tight junctions.

Literature References
PubMed ID Title Journal Year
9233797 Mechanism of TGFbeta receptor inhibition by FKBP12

Chen, YG, Liu, F, Massague, J

EMBO J 1997
15761148 Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

Ozdamar, B, Bose, R, Barrios-Rodiles, M, Wang, HR, Zhang, Y, Wrana, JL

Science 2005
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