Reactome | PARD6A [cell junction]

PARD6A [cell junction]

Stable Identifier

R-HSA-2134480

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cell junction

Synonyms

Partitioning defective 6 homolog alpha, PAR6A_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by TGF-beta family members (Homo sapiens)
  - Signaling by TGF-beta Receptor Complex (Homo sapiens)
    - TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)
      - TGFBR1 is recruited to tight junctions by PARD6A (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD6A [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD6A [cell junction] (Homo sapiens)
      - TGFBR2 is recruited to tight junctions after TGF-beta stimulation (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD6A [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD6A [cell junction] (Homo sapiens)
      - TGFBR2 phosphorylates TGFBR1 and PARD6A (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        PARD6A [cell junction] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NPB6 PARD6A

Gene Names

PARD6A, PAR6A

Chain

chain:1-346

Reference Genes

BioGPS Gene:50855 PARD6A

COSMIC (genes):PARD6A PARD6A

CTD Gene:50855 PARD6A

dbSNP Gene:50855 PARD6A

ENSEMBL:ENSG00000102981 PARD6A

HGNC:15943 PARD6A

KEGG Gene (Homo sapiens):50855 PARD6A

Monarch:50855 PARD6A

NCBI Gene:50855 PARD6A

OMIM:607484 PARD6A

UCSC:Q9NPB6 PARD6A

Reference Transcript

Other Identifiers

0000840086

11715230_s_at

16820249

1WMH

205245_at

3665724

3665725

3665728

3665732

3665733

3665734

37444_at

41551

50855

7996647

9733

A_14_P101481

A_23_P140821

AAB84252

AAF71529

AAF75548

AAH15626

AB041642

AB043634

AF028827

AF252292

AF265565

AJ277095

BAA96235

BAB16105

BC015626

CAB009733

CAB85490

CCDS10843

CCDS45514

ENSG00000102981

ENSP00000219255

ENSP00000392388

ENST00000219255

ENST00000219255.3

ENST00000458121

ENST00000458121.6

EntrezGene:50855

EntrezGene:PARD6A

g8394416_3p_at

GE58744

GO:0001726

GO:0001933

GO:0003674

GO:0005080

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005923

GO:0005938

GO:0006464

GO:0006810

GO:0007010

GO:0007049

GO:0007098

GO:0007163

GO:0007165

GO:0007179

GO:0007267

GO:0008134

GO:0008150

GO:0015031

GO:0016020

GO:0016032

GO:0016324

GO:0017048

GO:0019899

GO:0022607

GO:0030054

GO:0030742

GO:0034330

GO:0034451

GO:0042995

GO:0043226

GO:0044403

GO:0045217

GO:0048856

GO:0050714

GO:0051301

GO:0060071

GO:0060341

GO:0070830

GO:1904781

HGNC:15943

HPA041551

ILMN_1654112

ILMN_2323848

IPR000270

IPR001478

IPR034868

IPR034872

IPR036034

MIM:607484

NM_001037281

NM_016948

NP_001032358

NP_058644

PARD6A

PARD6A-201

PARD6A-202

PF00564

PF00595

PH_hs_0006209

R4GMM2

SM00228

SM00666

TC16000544.hg

UPI000006F1C0

UPI0000070183

XM_005255977

XM_011523095

XP_005256034

XP_011521397

Participant Of

hasComponent

PARD3:PARD6A:PRKCZ [cell junction]

Other forms of this molecule

p-S345-PARD6A [plasma membrane]

PARD6A [plasma membrane]

PARD6A [cytosol]

Cross References

RefSeq

NP_058644.1, NP_001032358.1

OpenTargets

ENSG00000102981

HPA

ENSG00000102981-PARD6A

GeneCards

Q9NPB6

Ensembl

ENSG00000102981, ENST00000458121, ENSP00000392388, ENSP00000219255, ENST00000219255

PRO

Q9NPB6

PDB

1WMH

HMDB Protein

HMDBP08500

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41743 PRKCI	3	PRKCI [cytosol] (R-HSA-58206) PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [plasma membrane] (R-HSA-420005)	0.949	17
UniProt:Q05513 PRKCZ	5	p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) p-T410-PRKCZ [cytosol] (R-HSA-437181) PRKCZ [cytosol] (R-HSA-58218) PRKCZ [cell junction] (R-HSA-2134483) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.872	8
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [plasma membrane] (R-HSA-449545)	0.755	7
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.508	2

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