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Disassociation of PLC-gamma1 from LAT
Stable Identifier
R-HSA-213406
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
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Immune System (Homo sapiens)
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TCR signaling (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
Disassociation of PLC-gamma1 from LAT (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The activated PLC-gamma1 detaches from its substrate LAT and translocates to the membrane.
Literature References
PubMed ID
Title
Journal
Year
11048639
The mechanism of phospholipase C-gamma1 regulation
Suh, PG
,
Kim, MJ
,
Kim, E
,
Ryu, SH
Exp Mol Med
2000
Participants
Input
phosphorylated PLC-gamma1 bound to LAT [plasma membrane]
(Homo sapiens)
Output
p-5Y-LAT [plasma membrane]
(Homo sapiens)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(Homo sapiens)
Participates
as an event of
Generation of second messenger molecules (Homo sapiens)
Orthologous Events
Disassociation of PLC-gamma1 from LAT (Bos taurus)
Disassociation of PLC-gamma1 from LAT (Canis familiaris)
Disassociation of PLC-gamma1 from LAT (Mus musculus)
Disassociation of PLC-gamma1 from LAT (Rattus norvegicus)
Disassociation of PLC-gamma1 from LAT (Sus scrofa)
Authored
Garapati, P V (2008-01-24)
Rudd, C.E. (2008-01-24)
de Bono, B (2008-01-24)
Reviewed
Trowsdale, J (2008-02-26)
Created
Garapati, P V (2008-02-26)
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