Formation of COPII vesicle

Stable Identifier
R-HSA-2130731
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Immediately after assembly in the ER nonameric (alpha beta:Ii)3 complexes egress from ER, facilitated by the presence of Ii, and enter the Golgi complex (Wolf & Ploegh 1995, Geuze 1998). Incorrectly folded or oligomerized alpha, beta and Ii chains are retained in the ER and degraded. The Sec23/24-Sar1 pre-budding complex binds to the nonameric complex and then recruits Sec13/31 outer shell, which buds off from the membrane as a coat protein complex II (COPII) vesicle to be transported to the Golgi complex (Bickford et al. 2004).

Literature References
PubMed ID Title Journal Year
2391366 Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens

Marks, MS, Blum, JS, Cresswell, P

J Cell Biol 1990
11790530 Trafficking of MHC class II molecules in the late secretory pathway

Hiltbold, EM, Roche, PA

Curr Opin Immunol 2002
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created