Reactome | Formation of COPII vesicle

Formation of COPII vesicle

Stable Identifier

R-HSA-2130731

Type

Reaction [binding]

Species

Homo sapiens

Compartment

COPII-coated ER to Golgi transport vesicle, endoplasmic reticulum membrane, lumenal side of endoplasmic reticulum membrane

ReviewStatus

5/5

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Immediately after assembly in the ER nonameric (alpha beta:Ii)3 complexes egress from ER, facilitated by the presence of Ii, and enter the Golgi complex (Wolf & Ploegh 1995, Geuze 1998). Incorrectly folded or oligomerized alpha, beta and Ii chains are retained in the ER and degraded. The Sec23/24-Sar1 pre-budding complex binds to the nonameric complex and then recruits Sec13/31 outer shell, which buds off from the membrane as a coat protein complex II (COPII) vesicle to be transported to the Golgi complex (Bickford et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
11790530	Trafficking of MHC class II molecules in the late secretory pathway Roche, PA, Hiltbold, EM	Curr Opin Immunol	2002
2391366	Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens Marks, MS, Blum, JS, Cresswell, P	J Cell Biol	1990