Recruitment of clathrin coated vesicle by Ii

Stable Identifier
R-HSA-2130640
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Plasma membrane-associated nonameric complexes (MHC II alpha/beta/Ii complex) are rapidly internalized and delivered to late endosomes (LEs) and lysosomes. The dileucine-based signal present in the cytoplasmic tail of Ii is required for sorting of the nonameric MHC II-Ii complex from the plasma membrane to peptide loading compartments. These signals promote rapid internalization by recognising and binding to clathrin adaptor AP-2, a scaffolding-protein complex that brings together components of the vesicle-formation machinery. AP-2 is an essential component of an endocytic clathrin coat and participates in initiation of coat assembly. The critical role of AP2 in delivering MHC II:Ii complex to antigen processing compartments came from RNA interference studies targeting clathrin and AP2. The knockout of AP2 profoundly inhibited MHC II:Ii complex internalization and resulted in the accumulation of Ii at the surface (Dugast et al. 2005, McCormick et al. 2005).

Literature References
PubMed ID Title Journal Year
8397411 Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization

Roche, PA, Teletski, CL, Stang, E, Bakke, O, Long, EO

Proc Natl Acad Sci U S A 1993
15749704 AP2 clathrin adaptor complex, but not AP1, controls the access of the major histocompatibility complex (MHC) class II to endosomes

Dugast, M, Toussaint, H, Dousset, C, Benaroch, P

J Biol Chem 2005
15911768 Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments

McCormick, PJ, Martina, JA, Bonifacino, JS

Proc Natl Acad Sci U S A 2005
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