Reactome | MHC class II antigen internalization

MHC class II antigen internalization

Stable Identifier

R-HSA-2130627

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

extracellular region, lysosomal lumen

ReviewStatus

5/5

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MHC II typically presents antigens derived from exogenous proteins internalized by APCs such as macrophages, B cells or dendritic cells. Different types of antigen use different routes of internalization. Endocytosis may be specific, mediated by a range of receptors expressed on APC, or may occur by nonspecific mechanisms such as phagocytosis, macropinocytosis or autophagy. Antigens are first loaded into endocytic vesicles and progress along the early endosomes (EE)-late endosomes (LE) lysosomal axis. Antigens are exposed to increasingly acidic, more denaturing and proteolytic conditions (Doherty & McMahon 2009, Underhill & Ozinsky 2002).

Literature References

PubMed ID	Title	Journal	Year
8970738	Endocytosis and molecular sorting Mellman, I	Annu Rev Cell Dev Biol	1996
11714749	Processing of Mycobacterium tuberculosis antigen 85B involves intraphagosomal formation of peptide-major histocompatibility complex II complexes and is inhibited by live bacilli that decrease phagosome maturation Harding, CV, Noss, E, Ramachandra, L, Boom, WH	J Exp Med	2001
10092778	Phagosomes are fully competent antigen-processing organelles that mediate the formation of peptide:class II MHC complexes Harding, CV, Ramachandra, L, Song, R	J Immunol	1999
19317650	Mechanisms of endocytosis McMahon, HT, Doherty, GJ	Annu Rev Biochem	2009