MHC class II antigen internalization

Stable Identifier
Reaction [omitted]
Homo sapiens
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MHC II typically presents antigens derived from exogenous proteins internalized by APCs such as macrophages, B cells or dendritic cells. Different types of antigen use different routes of internalization. Endocytosis may be specific, mediated by a range of receptors expressed on APC, or may occur by nonspecific mechanisms such as phagocytosis, macropinocytosis or autophagy. Antigens are first loaded into endocytic vesicles and progress along the early endosomes (EE)-late endosomes (LE) lysosomal axis. Antigens are exposed to increasingly acidic, more denaturing and proteolytic conditions (Doherty & McMahon 2009, Underhill & Ozinsky 2002).

Literature References
PubMed ID Title Journal Year
11714749 Processing of Mycobacterium tuberculosis antigen 85B involves intraphagosomal formation of peptide-major histocompatibility complex II complexes and is inhibited by live bacilli that decrease phagosome maturation

Harding, CV, Noss, E, Ramachandra, L, Boom, WH

J Exp Med 2001
10092778 Phagosomes are fully competent antigen-processing organelles that mediate the formation of peptide:class II MHC complexes

Harding, CV, Ramachandra, L, Song, R

J Immunol 1999
8970738 Endocytosis and molecular sorting

Mellman, I

Annu Rev Cell Dev Biol 1996
19317650 Mechanisms of endocytosis

McMahon, HT, Doherty, GJ

Annu Rev Biochem 2009
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