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HLA class II histocompatibility antigen, DRB1-12 beta chain [lysosomal membrane]
Stable Identifier
R-HSA-2130468
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
HLA-DRB1, 2B1C_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Cleavage of lip22 to lip10 (Homo sapiens)
MHC II:lip10 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-12 beta chain [lysosomal membrane] (Homo sapiens)
MHC II:lip22 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-12 beta chain [lysosomal membrane] (Homo sapiens)
Disassociation of CLIP from MHC II (Homo sapiens)
MHC II:CLIP [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-12 beta chain [lysosomal membrane] (Homo sapiens)
peptide free MHC II:HLA-DM [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-12 beta chain [lysosomal membrane] (Homo sapiens)
Generation of CLIP from lip10 (Homo sapiens)
MHC II:CLIP [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-12 beta chain [lysosomal membrane] (Homo sapiens)
MHC II:lip10 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-12 beta chain [lysosomal membrane] (Homo sapiens)
Initial proteolyis of Ii by aspartic proteases to lip22 (Homo sapiens)
MHC II:lip22 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-12 beta chain [lysosomal membrane] (Homo sapiens)
Nonameric complex [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-12 beta chain [lysosomal membrane] (Homo sapiens)
Loading of antigenic peptides (Homo sapiens)
peptide free MHC II:HLA-DM [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-12 beta chain [lysosomal membrane] (Homo sapiens)
peptide loaded MHC class II [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-12 beta chain [lysosomal membrane] (Homo sapiens)
TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Homo sapiens)
Nonameric complex [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-12 beta chain [lysosomal membrane] (Homo sapiens)
Trafficking of nonameric complex in the endocytic pathway (Homo sapiens)
Nonameric complex [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-12 beta chain [lysosomal membrane] (Homo sapiens)
Transport of antigen loaded MHC II molecules to surface (Homo sapiens)
peptide loaded MHC class II [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-12 beta chain [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q95IE3 HLA-DRB1
Gene Names
HLA-DRB1
Chain
signal peptide:1-29, chain:30-266
Reference Genes
BioGPS Gene:3123 HLA-DRB1
COSMIC (genes):HLA-DRB1 HLA-DRB1
CTD Gene:3123 HLA-DRB1
dbSNP Gene:3123 HLA-DRB1
ENSEMBL:ENSG00000196126 HLA-DRB1
ENSEMBL:ENSG00000228080 HLA-DRB1
KEGG Gene (Homo sapiens):3123 HLA-DRB1
Monarch:3123 HLA-DRB1
NCBI Gene:3123 HLA-DRB1
UCSC:Q95IE3 HLA-DRB1
Reference Transcript
RefSeq:NM_001243965.1 HLA-DRB1
RefSeq:XM_011547738.2 HLA-DRB1
RefSeq:NM_002124.3 HLA-DRB1
Participates
as a member of
HLA II beta chain [lysosomal membrane] (Homo sapiens)
Other forms of this molecule
HLA class II histocompatibility antigen, DRB1-12 beta chain [integral component of lumenal side of endoplasmic reticulum membrane]
HLA class II histocompatibility antigen, DRB1-12 beta chain [ER to Golgi transport vesicle membrane]
HLA class II histocompatibility antigen, DRB1-12 beta chain [Golgi membrane]
HLA class II histocompatibility antigen, DRB1-12 beta chain [trans-Golgi network membrane]
HLA class II histocompatibility antigen, DRB1-12 beta chain [transport vesicle membrane]
HLA class II histocompatibility antigen, DRB1-12 beta chain [clathrin-coated endocytic vesicle membrane]
HLA class II histocompatibility antigen, DRB1-12 beta chain [endocytic vesicle membrane]
HLA class II histocompatibility antigen, DRB1-12 beta chain [plasma membrane]
Cross References
RefSeq
NP_001230894.1
,
XP_011546040.1
,
NP_002115.2
OpenTargets
ENSG00000196126
GeneCards
Q95IE3
PRO
Q95IE3
Pharos - Targets
Q95IE3
PDB
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