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Transport of MHC II:Ii complex along Golgi to TGN
Stable Identifier
R-HSA-2130393
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
trans-Golgi network membrane
,
Golgi membrane
Synonyms
Translocation of MHC II:Ii complex to TGN
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Transport of MHC II:Ii complex along Golgi to TGN (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Nonameric MHC II:Ii complex move through the various cisternae to reach the trans-golgi network (TGN), a tubulo-vesicular organelle located at the trans-face of Golgi stacks. From the TGN, MHC II:Ii complexes are targeted to the endocytic pathway for peptide loading.
Literature References
PubMed ID
Title
Journal
Year
11790530
Trafficking of MHC class II molecules in the late secretory pathway
Roche, PA
,
Hiltbold, EM
Curr Opin Immunol
2002
11529500
Trans-Golgi network sorting
Crump, CM
,
Gu, F
,
Thomas, G
Cell Mol Life Sci
2001
10480952
Direct transport of newly synthesized HLA-DR from the trans-Golgi network to major histocompatibility complex class II containing compartments (MIICS) demonstrated using a novel tyrosine-sulfated chimera
Davidson, HW
J Biol Chem
1999
Participants
Input
Nonameric complex [Golgi membrane]
(Homo sapiens)
Output
Nonameric complex [trans-Golgi network membrane]
(Homo sapiens)
Participates
as an event of
MHC class II antigen presentation (Homo sapiens)
Orthologous Events
Transport of MHC II:Ii complex along Golgi to TGN (Bos taurus)
Transport of MHC II:Ii complex along Golgi to TGN (Canis familiaris)
Transport of MHC II:Ii complex along Golgi to TGN (Danio rerio)
Transport of MHC II:Ii complex along Golgi to TGN (Mus musculus)
Transport of MHC II:Ii complex along Golgi to TGN (Rattus norvegicus)
Transport of MHC II:Ii complex along Golgi to TGN (Sus scrofa)
Authored
Garapati, P V (2012-02-21)
Reviewed
Neefjes, J (2012-05-14)
Created
Garapati, P V (2012-02-21)
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