Reactome | HLA class II histocompatibility antigen, DM alpha chain precursor [lysosomal membrane]

HLA class II histocompatibility antigen, DM alpha chain precursor [lysosomal membrane]

Stable Identifier

R-HSA-2130359

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal membrane

Synonyms

2DMA_HUMAN, HLA-DMA

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P28067 HLA-DMA

Gene Names

HLA-DMA, DMA, RING6

Chain

signal peptide:1-26, chain:27-261

Reference Genes

COSMIC (genes):HLA-DMA HLA-DMA

ENSEMBL:ENSG00000204257 HLA-DMA

ENSEMBL:ENSG00000204257.15 HLA-DMA

ENSEMBL:ENSG00000239463.7 HLA-DMA

ENSEMBL:ENSG00000242361.7 HLA-DMA

ENSEMBL:ENSG00000242685.7 HLA-DMA

ENSEMBL:ENSG00000243189.7 HLA-DMA

ENSEMBL:ENSG00000243215.7 HLA-DMA

ENSEMBL:ENSG00000243719.7 HLA-DMA

HGNC:4934 HLA-DMA

OMIM:142855 HLA-DMA

Other Identifiers

0004150739

11716554_a_at

11745989_a_at

17018011

17037303

17042519

217478_PM_s_at

217478_s_at

2950278

2950279

2950281

2950283

2950284

2950286

2950287

2950288

2950293

2950294

3108

37344_at

8125537

8178884

8180086

A_23_P42306

A_24_P50245

GE59882

GO:0002250

GO:0002376

GO:0002503

GO:0002504

GO:0005515

GO:0005622

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005886

GO:0006955

GO:0007155

GO:0009986

GO:0010008

GO:0016020

GO:0016021

GO:0019882

GO:0019886

GO:0023026

GO:0031410

GO:0031902

GO:0032991

GO:0042613

GO:0043226

GO:0043231

GO:0050870

GO:0065003

HMNXSV003012753

Hs.77522.1.S1_3p_a_at

ILMN_1695311

PH_hs_0023937

TC6_apd_hap1000118.hg

TC6_dbb_hap3000210.hg

X62744_at

Participates

as a component of

HLA-DM [lysosomal membrane] (Homo sapiens)

Inferred To

HLA class II histocompatibility antigen, DM alpha chain precursor [lysosomal membrane] (Danio rerio)

BOLA-DMA [lysosomal membrane] (Bos taurus)

b2m [lysosomal membrane] (Danio rerio)

Ghost homologue of HLA class II histocompatibility antigen, DM alpha chain precursor [lysosomal membrane] (Rattus norvegicus)

H2-DMa [lysosomal membrane] (Mus musculus)

Homologues of HLA class II histocompatibility antigen, DM alpha chain precursor [lysosomal membrane] (Danio rerio)

SLA-DMA [lysosomal membrane] (Sus scrofa)

mhc2a [lysosomal membrane] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000204257

GeneCards

P28067

HPA

ENSG00000204257-HLA-DMA

Ensembl

ENSG00000242685, ENSP00000395349, ENSP00000372717, ENST00000441375, ENSP00000410591, ENSG00000204257, ENSP00000392842, ENSG00000243719, ENSG00000239463, ENSP00000363976, ENST00000434337, ENST00000453490, ENST00000383230, ENSG00000242361, ENSP00000404018, ENSG00000243189, ENST00000450601, ENST00000374843, ENSP00000407198, ENST00000452615, ENSG00000243215

PRO

P28067

Pharos - Targets

P28067

PDB

1HDM, 4GBX, 2BC4, 4FQX

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02686 MBP	1	MBP [cytosol] (R-HSA-9614770)	0.462	6