MFAP2, MFAP5 bind microfibrils

Stable Identifier
Reaction [binding]
Homo sapiens
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Microfibrils are composed largely of fibrillin but also contain covalently-linked microfibril associated glycoproteins MAGP-1 (MFAP2) and MAGP-2 (MFAP5). MFAP2 is a structural component of almost all vertebrate microfibrils (Gibson et al. 1989, Trask et al. 2000, Jensen et al. 2001). It appears to be important for tissue development and/or homeostasis, including regulation of bone remodelling and deposition of tissue fat (Weinbaum et al. 2008). The C-terminal half of MFAP2 is rich in cysteines and contains a matrix-binding domain that facilitates interactions with fibrillin (Weinbaum et al. 2008). The related MFAP5 similarly binds to microfibrils (Gibson et al. 1998) but with a restricted expression profile.

Literature References
PubMed ID Title Journal Year
11481325 Protein interaction studies of MAGP-1 with tropoelastin and fibrillin-1

Jensen, SA, Reinhardt, DP, Gibson, MA, Weiss, AS

J. Biol. Chem. 2001
Participant Of
Orthologous Events
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