Reactome | Elastin cross-linking by lysyl oxidase

Elastin cross-linking by lysyl oxidase

Stable Identifier

R-HSA-2129375

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Soluble monomers of tropoelastin are cross-linked by the oxidative deamination of lysine residues, catalyzed by lysyl oxidase (LOX). The first step in the cross linking reaction is the oxidative formation of the delta-aldehyde, known as alpha aminoadipic semialdehyde or allysine (Partridge 1963). Subsequent spontaneous reactions lead to the formation of cross-links through dehydrolysinonorleucine and allysine aldol, a trifunctional cross-link dehydromerodesmosine and two tetrafunctional cross-links desmosine and isodesmosine (Lucero & Kagan 2006), which are unique to elastin.

Literature References

PubMed ID	Title	Journal	Year
16906757	Tropoelastin massively associates during coacervation to form quantized protein spheres Braet, F, Korkmaz, E, Clarke, AW, Arnspang, EC, Mithieux, SM, Weiss, AS	Biochemistry	2006
6123066	Lysyl oxidase: preparation and role in elastin biosynthesis Sullivan, KA, Kagan, HM	Methods Enzymol	1982