STRAP binds phosphorylated TGF-beta receptor complex

Stable Identifier
R-HSA-2127562
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
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STRAP binds phosphorylated TGF-beta receptor complex
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STRAP (serine-threonine kinase receptor-associated protein) binds to the activated TGF-beta receptor complex. In in vitro studies, STRAP is able to bind both TGFBR1 and TGFBR2 (Datta et al. 1998). This was deduced from experiments in which a recombinant mouse Strap and recombinant human TGFBR1 and TGFBR2 were expressed in COS1 cells. STRAP is also able to bind unphosphorylated TGF-beta receptor complex, but the physiological significance, if any, of this interaction is not known.

Literature References
PubMed ID Title Journal Year
9856985 Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling

Datta, PK, Chytil, A, Gorska, AE, Moses, HL

J Biol Chem 1998
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Strap binds phosphorylated TGF-beta receptor complex (Homo sapiens)
Authored
Orlic-Milacic, M  (2012-04-04)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-02-16)