STRAP binds phosphorylated TGF-beta receptor complex

Stable Identifier
R-HSA-2127562
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
STRAP binds phosphorylated TGF-beta receptor complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

STRAP (serine-threonine kinase receptor-associated protein) binds to the activated TGF-beta receptor complex. In in vitro studies, STRAP is able to bind both TGFBR1 and TGFBR2 (Datta et al. 1998). This was deduced from experiments in which a recombinant mouse Strap and recombinant human TGFBR1 and TGFBR2 were expressed in COS1 cells. STRAP is also able to bind unphosphorylated TGF-beta receptor complex, but the physiological significance, if any, of this interaction is not known.

Literature References
PubMed ID Title Journal Year
9856985 Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling

Datta, PK, Chytil, A, Gorska, AE, Moses, HL

J Biol Chem 1998
Participants
Input
Output
Participates
as an event of
Inferred From
Strap binds phosphorylated TGF-beta receptor complex (Homo sapiens)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-02-16)
Cite Us!