Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region]
Stable Identifier
R-HSA-2127511
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
3,4-Hyp Glu-Gal-Hyl collagen alpha-6(VI) chain, CO6A6_HUMAN, COL6A6
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
NCAM signaling for neurite out-growth (Homo sapiens)
NCAM1 interactions (Homo sapiens)
Interaction of NCAM1 with collagens (Homo sapiens)
Collagens [extracellular region] (Homo sapiens)
Tropocollagen type VI [extracellular region] (Homo sapiens)
Collagen alpha 3-6(VI) [extracellular region] (Homo sapiens)
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region] (Homo sapiens)
NCAM-1:Collagen complex [plasma membrane] (Homo sapiens)
Collagens [extracellular region] (Homo sapiens)
Tropocollagen type VI [extracellular region] (Homo sapiens)
Collagen alpha 3-6(VI) [extracellular region] (Homo sapiens)
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
Formation of collagen networks (Homo sapiens)
Collagen networks [extracellular region] (Homo sapiens)
Collagen type VI network [extracellular region] (Homo sapiens)
Collagen type VI tetramer [extracellular region] (Homo sapiens)
Tropocollagen type VI dimer [extracellular region] (Homo sapiens)
Tropocollagen type VI [extracellular region] (Homo sapiens)
Collagen alpha 3-6(VI) [extracellular region] (Homo sapiens)
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region] (Homo sapiens)
Network forming tropocollagens [extracellular region] (Homo sapiens)
Collagen type VI tetramer [extracellular region] (Homo sapiens)
Tropocollagen type VI dimer [extracellular region] (Homo sapiens)
Tropocollagen type VI [extracellular region] (Homo sapiens)
Collagen alpha 3-6(VI) [extracellular region] (Homo sapiens)
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region] (Homo sapiens)
Collagen biosynthesis and modifying enzymes (Homo sapiens)
Secretion of collagens (Homo sapiens)
Collagens and tropocollagens [extracellular region] (Homo sapiens)
Collagen type VI tetramer [extracellular region] (Homo sapiens)
Tropocollagen type VI dimer [extracellular region] (Homo sapiens)
Tropocollagen type VI [extracellular region] (Homo sapiens)
Collagen alpha 3-6(VI) [extracellular region] (Homo sapiens)
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region] (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Collagen degradation (Homo sapiens)
Collagen type VI degradation by MMP2,9,11 (Homo sapiens)
Collagen type VI fibril [extracellular region] (Homo sapiens)
Collagen type VI tetramer [extracellular region] (Homo sapiens)
Tropocollagen type VI dimer [extracellular region] (Homo sapiens)
Tropocollagen type VI [extracellular region] (Homo sapiens)
Collagen alpha 3-6(VI) [extracellular region] (Homo sapiens)
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region] (Homo sapiens)
ECM proteoglycans (Homo sapiens)
BGN binds Collagen types I, VI, (IX) (Homo sapiens)
BGN:Collagen types I, VI, (IX) [extracellular region] (Homo sapiens)
Collagen types I, VI, (IX) [extracellular region] (Homo sapiens)
Collagen type VI network [extracellular region] (Homo sapiens)
Collagen type VI tetramer [extracellular region] (Homo sapiens)
Tropocollagen type VI dimer [extracellular region] (Homo sapiens)
Tropocollagen type VI [extracellular region] (Homo sapiens)
Collagen alpha 3-6(VI) [extracellular region] (Homo sapiens)
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region] (Homo sapiens)
Collagen types I, VI, (IX) [extracellular region] (Homo sapiens)
Collagen type VI network [extracellular region] (Homo sapiens)
Collagen type VI tetramer [extracellular region] (Homo sapiens)
Tropocollagen type VI dimer [extracellular region] (Homo sapiens)
Tropocollagen type VI [extracellular region] (Homo sapiens)
Collagen alpha 3-6(VI) [extracellular region] (Homo sapiens)
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region] (Homo sapiens)
DCN binds collagen I, II, III, VI fibrils (Homo sapiens)
Collagen type I, II, III, VI fibrils [extracellular region] (Homo sapiens)
Collagen type VI fibril [extracellular region] (Homo sapiens)
Collagen type VI tetramer [extracellular region] (Homo sapiens)
Tropocollagen type VI dimer [extracellular region] (Homo sapiens)
Tropocollagen type VI [extracellular region] (Homo sapiens)
Collagen alpha 3-6(VI) [extracellular region] (Homo sapiens)
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region] (Homo sapiens)
DCN:Collagen type I, II, III, VI fibrils [extracellular region] (Homo sapiens)
Collagen type I, II, III, VI fibrils [extracellular region] (Homo sapiens)
Collagen type VI fibril [extracellular region] (Homo sapiens)
Collagen type VI tetramer [extracellular region] (Homo sapiens)
Tropocollagen type VI dimer [extracellular region] (Homo sapiens)
Tropocollagen type VI [extracellular region] (Homo sapiens)
Collagen alpha 3-6(VI) [extracellular region] (Homo sapiens)
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region] (Homo sapiens)
VTN binds collagens I, IV and VI (Homo sapiens)
Collagen type I,IV,VI [extracellular region] (Homo sapiens)
Collagen type VI fibril [extracellular region] (Homo sapiens)
Collagen type VI tetramer [extracellular region] (Homo sapiens)
Tropocollagen type VI dimer [extracellular region] (Homo sapiens)
Tropocollagen type VI [extracellular region] (Homo sapiens)
Collagen alpha 3-6(VI) [extracellular region] (Homo sapiens)
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region] (Homo sapiens)
VTN:Collagen type I,IV,VI [extracellular region] (Homo sapiens)
Collagen type I,IV,VI [extracellular region] (Homo sapiens)
Collagen type VI fibril [extracellular region] (Homo sapiens)
Collagen type VI tetramer [extracellular region] (Homo sapiens)
Tropocollagen type VI dimer [extracellular region] (Homo sapiens)
Tropocollagen type VI [extracellular region] (Homo sapiens)
Collagen alpha 3-6(VI) [extracellular region] (Homo sapiens)
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region] (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens)
Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Homo sapiens)
Collagen type VI network [extracellular region] (Homo sapiens)
Collagen type VI tetramer [extracellular region] (Homo sapiens)
Tropocollagen type VI dimer [extracellular region] (Homo sapiens)
Tropocollagen type VI [extracellular region] (Homo sapiens)
Collagen alpha 3-6(VI) [extracellular region] (Homo sapiens)
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region] (Homo sapiens)
Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Homo sapiens)
Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Homo sapiens)
Collagen type VI network [extracellular region] (Homo sapiens)
Collagen type VI tetramer [extracellular region] (Homo sapiens)
Tropocollagen type VI dimer [extracellular region] (Homo sapiens)
Tropocollagen type VI [extracellular region] (Homo sapiens)
Collagen alpha 3-6(VI) [extracellular region] (Homo sapiens)
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region] (Homo sapiens)
Collagen types VI, IX bind integrin alpha10beta1 (Homo sapiens)
Collagen tupe VI network, Collagen type IX:Integrin alpha10beta1 [plasma membrane] (Homo sapiens)
Collagen type VI network, Collagen type IX [extracellular region] (Homo sapiens)
Collagen type VI network [extracellular region] (Homo sapiens)
Collagen type VI tetramer [extracellular region] (Homo sapiens)
Tropocollagen type VI dimer [extracellular region] (Homo sapiens)
Tropocollagen type VI [extracellular region] (Homo sapiens)
Collagen alpha 3-6(VI) [extracellular region] (Homo sapiens)
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region] (Homo sapiens)
Collagen type VI network, Collagen type IX [extracellular region] (Homo sapiens)
Collagen type VI network [extracellular region] (Homo sapiens)
Collagen type VI tetramer [extracellular region] (Homo sapiens)
Tropocollagen type VI dimer [extracellular region] (Homo sapiens)
Tropocollagen type VI [extracellular region] (Homo sapiens)
Collagen alpha 3-6(VI) [extracellular region] (Homo sapiens)
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
PDGF binds to extracellular matrix proteins (Homo sapiens)
Extracellular matrix ligands [extracellular region] (Homo sapiens)
Collagens [extracellular region] (Homo sapiens)
Tropocollagen type VI [extracellular region] (Homo sapiens)
Collagen alpha 3-6(VI) [extracellular region] (Homo sapiens)
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region] (Homo sapiens)
PDGF A and B chains:ECM complex [extracellular region] (Homo sapiens)
Extracellular matrix ligands [extracellular region] (Homo sapiens)
Collagens [extracellular region] (Homo sapiens)
Tropocollagen type VI [extracellular region] (Homo sapiens)
Collagen alpha 3-6(VI) [extracellular region] (Homo sapiens)
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:A6NMZ7 COL6A6
Gene Names
COL6A6
Chain
signal peptide:1-19, chain:20-2263
Reference Genes
BioGPS Gene:131873 COL6A6
COSMIC (genes):COL6A6 COL6A6
CTD Gene:131873 COL6A6
dbSNP Gene:131873 COL6A6
ENSEMBL:ENSG00000206384 COL6A6
HGNC:27023 COL6A6
KEGG:hsa:131873 COL6A6
Monarch:131873 COL6A6
NCBI Gene:131873 COL6A6
OMIM:616613 COL6A6
UCSC:A6NMZ7 COL6A6
Reference Transcript
RefSeq:XM_011512428.2 COL6A6
RefSeq:XM_017005715.1 COL6A6
RefSeq:XM_017005711.1 COL6A6
RefSeq:XM_017005713.1 COL6A6
RefSeq:XM_011512425.2 COL6A6
RefSeq:XM_017005712.1 COL6A6
RefSeq:NM_001102608.1 COL6A6
RefSeq:XM_005247121.4 COL6A6
RefSeq:XM_017005714.1 COL6A6
RefSeq:XM_011512426.2 COL6A6
Other Identifiers
11756896_a_at
131873
16945540
16945543
230867_PM_at
230867_at
242641_PM_at
242641_at
2642182
2642183
2642184
2642185
2642188
2642191
2642192
2642193
2642195
2642196
2642197
2642198
2642201
2642202
2642203
2642206
2642207
2642208
2642209
2642210
2642211
2642213
2642214
2642215
2642216
2642217
2642218
2642219
2642221
2642223
2642226
2642227
2642229
2642232
2642233
2642234
2642235
2642236
2642242
2642243
2642244
2642246
2642248
2642252
2642253
2642258
2642259
2642260
2642291
2642293
63451_at
8082597
88669_at
A_14_P129368
A_32_P224525
GE574205
GO:0005198
GO:0005576
GO:0005581
GO:0007155
GO:0030020
GO:0030312
GO:0031012
GO:0062023
HMNXSV003050187
Hs.120388.0.A1_3p_at
Hs.263560.1.A1_3p_at
ILMN_1815679
PH_hs_0023311
TC03000705.hg
TC03002544.hg
TC03002545.hg
p28575
Participates
as a member of
Collagen alpha-6(VI) chains [extracellular region] (Homo sapiens)
Other forms of this molecule
3Hyp-4Hyp-GalHyl-COL6A6 [endoplasmic reticulum lumen]
GalHyl-COL6A6 [endoplasmic reticulum lumen]
GlcGalHyl-COL6A6 [endoplasmic reticulum lumen]
4Hyp-GalHyl-COL6A6 [endoplasmic reticulum lumen]
4Hyp-GlcGalHyl-COL6A6 [endoplasmic reticulum lumen]
3Hyp-4Hyp-GlcGalHyl-COL6A6 [endoplasmic reticulum lumen]
4Hyp-5Hyl-COL6A6 [extracellular region]
COL6A6 [extracellular region]
4Hyp-GalHyl-COL6A6 [extracellular region]
5Hyl-COL6A6 [extracellular region]
3Hyp-4Hyp-5Hyl-COL6A6 [extracellular region]
GlcGalHyl-COL6A6 [extracellular region]
4Hyp-GlcGalHyl-COL6A6 [extracellular region]
4Hyp-COL6A6 [extracellular region]
3Hyp-4Hyp-COL6A6 [extracellular region]
3Hyp-4Hyp-GalHyl-COL6A6 [extracellular region]
GalHyl-COL6A6 [extracellular region]
3Hyp-4Hyp-GlcGalHyl-COL6A6(20-?) [extracellular region]
4Hyp-GlcGalHyl-COL6A6(20-?) [extracellular region]
4Hyp-5Hyl-COL6A6(?-2263) [extracellular region]
3Hyp-4Hyp-5Hyl-COL6A6(?-2263) [extracellular region]
3Hyp-4Hyp-GlcGalHyl-COL6A6(?-2263) [extracellular region]
4Hyp-COL6A6(?-2263) [extracellular region]
4Hyp-COL6A6(20-?) [extracellular region]
3Hyp-4Hyp-GalHyl-COL6A6(?-2263) [extracellular region]
4Hyp-GalHyl-COL6A6(?-2263) [extracellular region]
GalHyl-COL6A6(20-?) [extracellular region]
COL6A6(20-?) [extracellular region]
GlcGalHyl-COL6A6(?-2263) [extracellular region]
5Hyl-COL6A6(?-2263) [extracellular region]
4Hyp-GlcGalHyl-COL6A6(?-2263) [extracellular region]
4Hyp-GalHyl-COL6A6(20-?) [extracellular region]
3Hyp-4Hyp-GalHyl-COL6A6(20-?) [extracellular region]
5Hyl-COL6A6(20-?) [extracellular region]
COL6A6(?-2263) [extracellular region]
4Hyp-5Hyl-COL6A6(20-?) [extracellular region]
GalHyl-COL6A6(?-2263) [extracellular region]
GlcGalHyl-COL6A6(20-?) [extracellular region]
3Hyp-4Hyp-COL6A6(?-2263) [extracellular region]
5Hyl-COL6A6 [endoplasmic reticulum lumen]
3Hyp-4Hyp-5Hyl-COL6A6 [endoplasmic reticulum lumen]
4Hyp-5Hyl-COL6A6 [endoplasmic reticulum lumen]
3Hyp-4Hyp-COL6A6 [endoplasmic reticulum lumen]
4Hyp-COL6A6 [endoplasmic reticulum lumen]
COL6A6 [endoplasmic reticulum lumen]
Inferred To
Col6a6 [extracellular region]
(Mus musculus)
3Hyp-4Hyp-GlcGalHyl-COL6A6 [extracellular region]
(Caenorhabditis elegans)
COL6A6 [extracellular region]
(Bos taurus)
COL6A6 [extracellular region]
(Sus scrofa)
Modified Residues
Name
(2S,4R)-4-hydroxyproline at unknown position
PsiMod Name
(2S,4R)-4-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
Name
(2S,3S)-3-hydroxyproline at unknown position
PsiMod Name
(2S,3S)-3-hydroxyproline
PsiMod Definition
A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.
Name
O5-glucosylgalactosyl-L-hydroxylysine at unknown position
PsiMod Name
O5-glucosylgalactosyl-L-hydroxylysine
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to O5-glucosylgalactosyl-L-hydroxylysine.
Cross References
RefSeq
XP_011510730.1
,
XP_016861202.1
,
XP_016861200.1
,
NP_001096078.1
,
XP_016861201.1
,
XP_016861203.1
,
XP_005247178.1
,
XP_011510728.1
,
XP_011510727.1
,
XP_016861204.1
OpenTargets
ENSG00000206384
ENSEMBL
ENST00000358511
,
ENSP00000351310
HPA
ENSG00000206384-COL6A6
PRO
A6NMZ7
Pharos - Targets
A6NMZ7
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text