Reactome | 3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region]

3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region]

Stable Identifier

R-HSA-2127386

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

3x4Hyp-3Hyp-COL4A1, 3,4-hydroxyprolyl collagen alpha-1(IV) chain

Locations in the PathwayBrowser

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Extracellular matrix organization (Homo sapiens)

- Collagen formation (Homo sapiens)
  - Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
    - Anchoring fibril formation (Homo sapiens)
      - Collagen type VII binds laminin-322 and collagen IV (Homo sapiens)
        
        Anchoring fibril complex [extracellular region] (Homo sapiens)
        
        Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
    - Crosslinking of collagen fibrils (Homo sapiens)
      - Collagen type IV sulfilimine cross-linking by peroxidasin (Homo sapiens)
        
        Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV networks with sulfilimine cross-links [extracellular region] (Homo sapiens)
        
        Sulfilimine-containing collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) with or without sulfilimine cross-links [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Sulfilimine-containing collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens with or without sulfilimine cross-links [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) with or without sulfiliminyl cross-links [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
    - Formation of collagen networks (Homo sapiens)
      - Collagen networks [extracellular region] (Homo sapiens)
        
        Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
      - Network forming tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen type IV [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
- Degradation of the extracellular matrix (Homo sapiens)
  - Collagen degradation (Homo sapiens)
    - Collagen type IV degradation by MMP2,3,4,9,10,12 (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
- ECM proteoglycans (Homo sapiens)
  - VTN binds collagens I, IV and VI (Homo sapiens)
    - Collagen type I,IV,VI [extracellular region] (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
    - VTN:Collagen type I,IV,VI [extracellular region] (Homo sapiens)
      - Collagen type I,IV,VI [extracellular region] (Homo sapiens)
        
        Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
- FN1 binds Collagen types I-V, VII (Homo sapiens)
  - Collagen types I-V, VII [extracellular region] (Homo sapiens)
    - Collagen type IV networks [extracellular region] (Homo sapiens)
      - Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
      - Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
  - FN1(32-2386):Collagen types I-V, VII [extracellular region] (Homo sapiens)
    - Collagen types I-V, VII [extracellular region] (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
- Integrin cell surface interactions (Homo sapiens)
  - Collagen type IV binds integrin alpha10beta1 (Homo sapiens)
    - Collagen type IV networks [extracellular region] (Homo sapiens)
      - Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
      - Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
    - Collagen type IV networks:Integrin alpha10beta1 [plasma membrane] (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
  - Collagen type IV networks bind integrins alpha1beta1, alpha2beta1 (Homo sapiens)
    - Collagen type IV networks [extracellular region] (Homo sapiens)
      - Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
      - Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
    - Integrins alpha1beta1, alpha2beta1:Collagen type IV networks:Mg2+ [plasma membrane] (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
  - Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens)
    - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
    - Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Homo sapiens)
      - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Homo sapiens)
        
        Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
- Laminin interactions (Homo sapiens)
  - Collagen type VII binds collagen type IV (Homo sapiens)
    - Collagen type IV networks [extracellular region] (Homo sapiens)
      - Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
      - Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
    - Collagen type IV networks:Collagen type VII fibril [extracellular region] (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
  - Laminin-111 binds collagen type IV (Homo sapiens)
    - Collagen type IV network:Laminin-1 [extracellular region] (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
    - Collagen type IV networks [extracellular region] (Homo sapiens)
      - Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
      - Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
  - Laminins:Nidogens binds collagen type IV networks (Homo sapiens)
    - Collagen type IV networks [extracellular region] (Homo sapiens)
      - Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
      - Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
    - Laminins with gamma-1, gamma-3:Nidogens:Collagen type IV network [extracellular region] (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
- Non-integrin membrane-ECM interactions (Homo sapiens)
  - DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Homo sapiens)
    - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
    - DDR1 dimer:Collagen type I, II, III, IV, V, XI fibrils [plasma membrane] (Homo sapiens)
      - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Homo sapiens)
        
        Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha1.alpha2 network [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-1(IV).alpha-1(IV).alpha-2(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-1(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02462 COL4A1

Gene Names

COL4A1

Chain

signal peptide:1-27, propeptide:28-172, chain:173-1669, chain:1445-1669

Reference Genes

BioGPS Gene:1282 COL4A1

COSMIC (genes):COL4A1 COL4A1

CTD Gene:1282 COL4A1

dbSNP Gene:1282 COL4A1

ENSEMBL:ENSG00000187498 COL4A1

ENSEMBL_homo_sapiens_GENE:ENSG00000187498 COL4A1

HGNC:2202 COL4A1

KEGG Gene (Homo sapiens):1282 COL4A1

Monarch:1282 COL4A1

NCBI Gene:1282 COL4A1

OMIM:120130 COL4A1

UCSC:P02462 COL4A1

Reference Transcript

Other Identifiers

0000060711

11716638_s_at

11716639_a_at

11760558_at

1282

16780929

1695

1LI1

211980_at

211981_at

3525314

3525315

3525316

3525317

3525318

3525319

3525320

3525321

3525324

3525326

3525327

3525330

3525331

3525332

3525333

3525334

3525337

3525338

3525341

3525343

3525345

3525346

3525347

3525350

3525352

3525354

3525355

3525356

3525357

3525358

3525359

3525360

3525362

3525363

3525365

3525366

3525367

3525371

3525373

3525374

3525376

3525378

3525380

3525382

3525383

3525385

3525387

3525388

3525389

3525392

3525393

3525394

3525395

3525397

3525399

3525400

3525401

3525403

3525405

3525414

3525433

3525434

39333_at

54039

59548_at

73188_s_at

7972750

A_23_P65240

A_24_P68342

AAA52006

AAA52042

AAA53098

AAF72630

AAH47305

AAI51221

AAK53382

AAK92480

AAM97359

AAP43112

ABE73157

AF258349

AF363672

AF400431

AF536207

AL161773

AL390755

AY285780

BC047305

BC151220

CAA29075

CAA68698

CAB001695

CCDS76649

CCDS9511

COL4A1

COL4A1-201

COL4A1-204

DQ464183

ENSG00000187498

ENSP00000364979

ENSP00000443348

ENST00000375820

ENST00000543140

EntrezGene:1282

GE635613

GE79587

GO:0001525

GO:0001569

GO:0003674

GO:0005198

GO:0005201

GO:0005515

GO:0005575

GO:0005576

GO:0005581

GO:0005587

GO:0005604

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005783

GO:0005788

GO:0007165

GO:0007420

GO:0007528

GO:0008150

GO:0030020

GO:0030154

GO:0030198

GO:0030855

GO:0031012

GO:0032991

GO:0038063

GO:0043226

GO:0048407

GO:0048514

GO:0048646

GO:0048856

GO:0061304

GO:0061333

GO:0062023

GO:0071230

GO:0071711

HGNC:2202

HPA054039

Hs.119129.0.A1_3p_at

Hs.119129.0.A2_3p_at

ILMN_1653028

IPR001442

IPR008160

IPR016187

IPR036954

J04217

KF455822

M10940

M11315

M26536

M26537

M26538

M26539

M26540

M26541

M26542

M26543

M26544

M26545

M26546

M26547

M26548

M26549

M26550

M26551

M26552

M26553

M26554

M26555

M26556

M26557

M26558

M26559

M26560

M26561

M26562

M26563

M26564

M26565

M26566

M26567

M26568

M26569

M26570

M26571

M26572

M26573

M26574

M26575

M26576

M26576_cds2_at

MIM:120130

MIM:175780

MIM:180000

MIM:269160

MIM:607595

MIM:611773

MIM:614519

NM_001303110

NM_001845

NP_001290039

NP_001836

PF01391

PF01413

PH_hs_0025581

SM00111

TC13000872.hg

uc001vqw.4

uc058yfq.1

UPI000004981D

UPI00020654AA

X05561

XM_011521048

XP_011519350

Y00706

Participant Of

hasMember

Collagen alpha-1(IV) chains [extracellular region]

Other forms of this molecule

GlcGalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen]

GalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-GalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen]

3x4Hyp-GlcGalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen]

3x4Hyp-GalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-GlcGalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen]

COL4A1(24-1669) [endoplasmic reticulum lumen]

3x4Hyp-COL4A1(24-1669) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-COL4A1(24-1669) [endoplasmic reticulum lumen]

3x4Hyp-5Hyl-COL4A1(24-1669) [endoplasmic reticulum lumen]

3x4Hyp-3Hyp-5Hyl-COL4A1(24-1669) [endoplasmic reticulum lumen]

5Hyl-COL4A1(24-1669) [endoplasmic reticulum lumen]

5-sulfiliminyl collagen alpha-1(IV) chain [extracellular region]

3,4-Hyp 5-sulfiliminyl collagen alpha-1(IV) chain [extracellular region]

4-Hyp 5-sulfiliminyl collagen alpha-1(IV) chain [extracellular region]

3x4Hyp-COL4A1(24-?) [extracellular region]

COL4A1(?-1669) [extracellular region]

3x4Hyp-GlcGalHyl-COL4A1(?-1669) [extracellular region]

COL4A1(24-?) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL4A1(24-?) [extracellular region]

GalHyl-COL4A1(24-?) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL4A1(24-?) [extracellular region]

GlcGalHyl-COL4A1(?-1669) [extracellular region]

3x4Hyp-GalHyl-COL4A1(?-1669) [extracellular region]

3x4Hyp-3Hyp-COL4A1(24-?) [extracellular region]

3x4Hyp-GalHyl-COL4A1(24-?) [extracellular region]

3x4Hyp-5Hyl-COL4A1(?-1669) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL4A1(24-?) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL4A1(?-1669) [extracellular region]

GlcGalHyl-COL4A1(24-?) [extracellular region]

3x4Hyp-5Hyl-COL4A1(24-?) [extracellular region]

5Hyl-COL4A1(24-?) [extracellular region]

3x4Hyp-3Hyp-COL4A1(?-1669) [extracellular region]

5Hyl-COL4A1(?-1669) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL4A1(?-1669) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL4A1(?-1669) [extracellular region]

3x4Hyp-GlcGalHyl-COL4A1(24-?) [extracellular region]

3x4Hyp-COL4A1(?-1669) [extracellular region]

GalHyl-COL4A1(?-1669) [extracellular region]

GlcGalHyl-COL4A1(173-1669) [extracellular region]

5Hyl-COL4A1(173-1669) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL4A1(173-1669) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL4A1(173-1669) [extracellular region]

GalHyl-COL4A1(173-1669) [extracellular region]

GlcGalHyl-COL4A1(1445-1669) [extracellular region]

3x4Hyp-5Hyl-COL4A1(1445-1669) [extracellular region]

3x4Hyp-3Hyp-GalHyl-COL4A1(1445-1669) [extracellular region]

5Hyl-COL4A1(1445-1669) [extracellular region]

3x4Hyp-GlcGalHyl-COL4A1((1445-1669)) [extracellular region]

GalHyl-COL4A1(1445-1669) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL4A1(1445-1669) [extracellular region]

3x4Hyp-COL4A1(1445-1669) [extracellular region]

3x4Hyp-3Hyp-5Hyl-COL4A1(1445-1669) [extracellular region]

3x4Hyp-3Hyp-COL4A1(1445-1669) [extracellular region]

3x4Hyp-GalHyl-COL4A1(1445-1669) [extracellular region]

COL4A1(1445-1669) [extracellular region]

3x4Hyp-GalHyl-COL4A1(173-1669) [extracellular region]

COL4A1(173-1669) [extracellular region]

3x4Hyp-GlcGalHyl-COL4A1(173-1669) [extracellular region]

3x4Hyp-5Hyl-COL4A1(173-1669) [extracellular region]

3x4Hyp-3Hyp-GlcGalHyl-COL4A1(173-1669) [extracellular region]

3x4Hyp-COL4A1(173-1669) [extracellular region]

Inferred To

3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Caenorhabditis elegans)

3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Canis familiaris)

3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Dictyostelium discoideum)

3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Drosophila melanogaster)

3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Mus musculus)

3x4Hyp-3Hyp-COL4A1(173-1669) [extracellular region] (Rattus norvegicus)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Cross References

RefSeq

NP_001290039.1, NP_001836.3

OpenTargets

ENSG00000187498

GeneCards

P02462

DOCK Blaster

1LI1

PRO

P02462

Orphanet

15771

PDB

5NAX, 1LI1, 5NAY