Reactome | 3x4Hyp-GlcGalHyl-COL4A6 [extracellular region]

3x4Hyp-GlcGalHyl-COL4A6

Stable Identifier

R-HSA-2127324

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

4-Hyp Glu-Gal-Hyl collagen alpha-6(IV) chain, COL4A6, CO4A6_HUMAN

Locations in the PathwayBrowser

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Extracellular matrix organization (Homo sapiens)

- Collagen formation (Homo sapiens)
  - Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
    - Anchoring fibril formation (Homo sapiens)
      - Collagen type VII binds laminin-322 and collagen IV (Homo sapiens)
        
        Anchoring fibril complex [extracellular region] (Homo sapiens)
        
        Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
        
        Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
    - Crosslinking of collagen fibrils (Homo sapiens)
      - Collagen type IV sulfilimine cross-linking by peroxidasin (Homo sapiens)
        
        Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
        
        Collagen type IV networks with sulfilimine cross-links [extracellular region] (Homo sapiens)
        
        Sulfilimine-containing collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens with or without sulfilimine cross-links [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) with or without sulfilimine cross-links [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
    - Formation of collagen networks (Homo sapiens)
      - Collagen networks [extracellular region] (Homo sapiens)
        
        Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
      - Network forming tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen type IV [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
- Degradation of the extracellular matrix (Homo sapiens)
  - Collagen degradation (Homo sapiens)
    - Collagen type IV degradation by MMP2,3,4,9,10,12 (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
- ECM proteoglycans (Homo sapiens)
  - VTN binds collagens I, IV and VI (Homo sapiens)
    - Collagen type I,IV,VI [extracellular region] (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
    - VTN:Collagen type I,IV,VI [extracellular region] (Homo sapiens)
      - Collagen type I,IV,VI [extracellular region] (Homo sapiens)
        
        Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
- FN1 binds Collagen types I-V, VII (Homo sapiens)
  - Collagen types I-V, VII [extracellular region] (Homo sapiens)
    - Collagen type IV networks [extracellular region] (Homo sapiens)
      - Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
  - FN1(32-2386):Collagen types I-V, VII [extracellular region] (Homo sapiens)
    - Collagen types I-V, VII [extracellular region] (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
- Integrin cell surface interactions (Homo sapiens)
  - Collagen type IV binds integrin alpha10beta1 (Homo sapiens)
    - Collagen type IV networks [extracellular region] (Homo sapiens)
      - Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
    - Collagen type IV networks:Integrin alpha10beta1 [plasma membrane] (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
  - Collagen type IV networks bind integrins alpha1beta1, alpha2beta1 (Homo sapiens)
    - Collagen type IV networks [extracellular region] (Homo sapiens)
      - Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
    - Integrins alpha1beta1, alpha2beta1:Collagen type IV networks:Mg2+ [plasma membrane] (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
  - Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens)
    - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
    - Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Homo sapiens)
      - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Homo sapiens)
        
        Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
- Laminin interactions (Homo sapiens)
  - Collagen type VII binds collagen type IV (Homo sapiens)
    - Collagen type IV networks [extracellular region] (Homo sapiens)
      - Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
    - Collagen type IV networks:Collagen type VII fibril [extracellular region] (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
  - Laminin-111 binds collagen type IV (Homo sapiens)
    - Collagen type IV network:Laminin-1 [extracellular region] (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
    - Collagen type IV networks [extracellular region] (Homo sapiens)
      - Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
  - Laminins:Nidogens binds collagen type IV networks (Homo sapiens)
    - Collagen type IV networks [extracellular region] (Homo sapiens)
      - Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
    - Laminins with gamma-1, gamma-3:Nidogens:Collagen type IV network [extracellular region] (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
- Non-integrin membrane-ECM interactions (Homo sapiens)
  - DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Homo sapiens)
    - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Homo sapiens)
      - Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)
    - DDR1 dimer:Collagen type I, II, III, IV, V, XI fibrils [plasma membrane] (Homo sapiens)
      - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Homo sapiens)
        
        Collagen type IV networks [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 network [extracellular region] (Homo sapiens)
        
        Collagen type IV alpha1.alpha2.alpha5.alpha6 tropocollagens [extracellular region] (Homo sapiens)
        
        Tropocollagen alpha-5(IV).alpha-5(IV).alpha-6(IV) [extracellular region] (Homo sapiens)
        
        Collagen alpha-6(IV) chains [extracellular region] (Homo sapiens)
        
        3x4Hyp-GlcGalHyl-COL4A6 [extracellular region] (Homo sapiens)