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MYC gene [nucleoplasm]
Stable Identifier
R-HSA-2127254
Type
DNA Sequence [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
MYC gene on chromosome 8
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Transcriptional regulation of granulopoiesis (Homo sapiens)
CEBPA binds MYC gene:E2F1 (Homo sapiens)
MYC gene:CEBPA:E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
MYC gene:E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
CEBPB and phospho-STAT3 bind the promoter of the MYC gene (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
MYC gene:phospho-STAT3:CEBPB [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
E2F1 binds the promoter of the MYC gene (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
MYC gene:E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
MYC gene:CEBPA:E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
MYC gene:E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
MYC gene:phospho-STAT3:CEBPB [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
NOTCH1 PEST domain mutants bind MYC promoter (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:MYC Gene [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants stimulate MYC transcription (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:MYC Gene [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
NOTCH1 PEST domain mutants bind MYC promoter (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:MYC Gene [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
NOTCH1 PEST domain mutants stimulate MYC transcription (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
NOTCH1 PEST Domain Mutants Coactivator Complex:MYC Gene [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
RUNX3 regulates WNT signaling (Homo sapiens)
TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
TCF7L1/TCF7L2/LEF1:CTNNB1:MYC gene [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
TCF7L1/TCF7L2/LEF1:CTNNB1:MYC gene [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated nuclear proteins (Homo sapiens)
STAT3-upregulated genes for nuclear proteins [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
NOTCH1 Coactivator Complex binds MYC promoter (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
NOTCH1 Coactivator Complex:MYC Gene [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
NOTCH1 stimulates MYC transcription (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
NOTCH1 Coactivator Complex:MYC Gene [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Homo sapiens)
KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Homo sapiens)
KDM4B-regulated estrogen-responsive genes [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Homo sapiens)
KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Homo sapiens)
KDM4B-regulated estrogen-responsive genes [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
ESR1:ESTG, JUND:FOSB and Cohesin Complex bind distal enhancer elements in MYC gene promoter (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
MYC gene:ESR1:ESTG:JUND:FOSB:Cohesin Complex [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
Estrogen-responsive MYC gene expression (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
MYC gene:ESR1:ESTG:JUND:FOSB:Cohesin Complex [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
MYC gene:HIST1H2AC nucleosome:ESR1:ESTG:EP300:NCOA3 [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
MYC gene:nucleoplasm:ESR1:ESTG [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Homo sapiens)
KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Homo sapiens)
KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Homo sapiens)
KDM4B-regulated estrogen-responsive genes [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
KDM4B-regulated genes:nucleosome:ESR1:ESTG [nucleoplasm] (Homo sapiens)
KDM4B-regulated estrogen-responsive genes [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
Signaling by TGF-beta family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
TCF/LEF:CTNNB1 bind canonical WNT target promoters (Homo sapiens)
'canonical' WNT target genes [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
Transcription of canonical WNT targets is negatively regulated by NLK-dependent phosphorylation of TCF/LEF (Homo sapiens)
'canonical' WNT target genes [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
Repression of WNT target genes (Homo sapiens)
TCF/LEF binds WNT promoters (Homo sapiens)
'canonical' WNT target genes [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
TLE recruits HDAC1 to WNT promoters (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm] (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
TLE tetramers bind TCF/LEF at WNT promoters (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes (Homo sapiens)
'canonical' WNT target genes [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm] (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Binding of TCF/LEF:CTNNB1 to target gene promoters (Homo sapiens)
TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
TCF7L1/TCF7L2/LEF1:CTNNB1:MYC gene [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
TCF7L1/TCF7L2/LEF1:CTNNB1:MYC gene [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)
MYC gene: H2B K121ub nucleosome [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Homo sapiens)
MYC gene [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
ENSEMBL:ENSG00000136997 MYC
Gene Names
MYC, BHLHE39
Participant Of
hasMember
KDM4B-regulated estrogen-responsive genes [nucleoplasm]
STAT3-upregulated genes for nuclear proteins [nucleoplasm]
input
CEBPB and phospho-STAT3 bind the promoter of the MYC gene
E2F1 binds the promoter of the MYC gene
ESR1:ESTG, JUND:FOSB and Cohesin Complex bind distal enhancer elements in MYC gene promoter
Estrogen-responsive MYC gene expression
MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA
MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex
NOTCH1 Coactivator Complex binds MYC promoter
NOTCH1 PEST domain mutants bind MYC promoter
NOTCH1 PEST domain mutants stimulate MYC transcription
NOTCH1 stimulates MYC transcription
TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene
TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene
hasComponent
MYC gene: H2B K121ub nucleosome [nucleoplasm]
MYC gene:CEBPA:E2F1:(TFDP1,TFDP2) [nucleoplasm]
MYC gene:E2F1:(TFDP1,TFDP2) [nucleoplasm]
MYC gene:ESR1:ESTG:JUND:FOSB:Cohesin Complex [nucleoplasm]
MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm]
MYC gene:HIST1H2AC nucleosome:ESR1:ESTG:EP300:NCOA3 [nucleoplasm]
MYC gene:nucleoplasm:ESR1:ESTG [nucleoplasm]
MYC gene:phospho-STAT3:CEBPB [nucleoplasm]
NOTCH1 Coactivator Complex:MYC Gene [nucleoplasm]
NOTCH1 PEST Domain Mutants Coactivator Complex:MYC Gene [nucleoplasm]
TCF7L1/TCF7L2/LEF1:CTNNB1:MYC gene [nucleoplasm]
hasCandidate
'canonical' WNT target genes [nucleoplasm]
Inferred To
Ghost homologue of MYC gene [nucleoplasm] (Bos taurus)
Ghost homologue of MYC gene [nucleoplasm] (Caenorhabditis elegans)
Ghost homologue of MYC gene [nucleoplasm] (Canis familiaris)
Ghost homologue of MYC gene [nucleoplasm] (Danio rerio)
Ghost homologue of MYC gene [nucleoplasm] (Dictyostelium discoideum)
Ghost homologue of MYC gene [nucleoplasm] (Mus musculus)
Ghost homologue of MYC gene [nucleoplasm] (Plasmodium falciparum)
Ghost homologue of MYC gene [nucleoplasm] (Rattus norvegicus)
Ghost homologue of MYC gene [nucleoplasm] (Sus scrofa)
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