Caspase mediated cleavage produces a constitutively active kinase that induces apoptosis (Ghayur et al.,1996).
Wong, W, Ghayur, T, Huang, Y, Ratnofsky, S, Hugunin, M, Emoto, Y, Kharbanda, S, Kufe, D, Kamen, R, Quinlan, C, Pandey, P, Talanian, RV, Allen, H, Datta, R
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
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