Caspase 3-mediated cleavage of PKC delta

Stable Identifier
R-HSA-212552
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Caspase 3-mediated cleavage of PKC delta
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Caspase mediated cleavage produces a constitutively active kinase that induces apoptosis (Ghayur et al.,1996).

Literature References
PubMed ID Title Journal Year
8976194 Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis

Ghayur, T, Hugunin, M, Talanian, RV, Ratnofsky, S, Quinlan, C, Emoto, Y, Pandey, P, Datta, R, Huang, Y, Kharbanda, S, Allen, H, Kamen, R, Wong, W, Kufe, D

J Exp Med 1996
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
Physical Entity
Caspase-3 [cytosol]
Activity
cysteine-type endopeptidase activity (0004197)
Orthologous Events
Caspase 3-mediated cleavage of PKC delta (Canis familiaris)
Caspase 3-mediated cleavage of PKC delta (Danio rerio)
Caspase 3-mediated cleavage of PKC delta (Drosophila melanogaster)
Caspase 3-mediated cleavage of PKC delta (Gallus gallus)
Caspase 3-mediated cleavage of PKC delta (Mus musculus)
Caspase 3-mediated cleavage of PKC delta (Rattus norvegicus)
Caspase 3-mediated cleavage of PKC delta (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2007-09-03)
Reviewed
Ranganathan, S  (2007-11-23)
Created
Matthews, L  (2008-02-12)