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TLE4 [nucleoplasm]
Stable Identifier
R-HSA-212377
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
HES1 binds TLE (Homo sapiens)
HES1:TLE [nucleoplasm] (Homo sapiens)
TLE [nucleoplasm] (Homo sapiens)
TLE4 [nucleoplasm] (Homo sapiens)
TLE [nucleoplasm] (Homo sapiens)
TLE4 [nucleoplasm] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
Repression of WNT target genes (Homo sapiens)
TLE forms non-functional complexes with AES (Homo sapiens)
TLE [nucleoplasm] (Homo sapiens)
TLE4 [nucleoplasm] (Homo sapiens)
TLE:AES [nucleoplasm] (Homo sapiens)
TLE [nucleoplasm] (Homo sapiens)
TLE4 [nucleoplasm] (Homo sapiens)
TLE oligomerizes (Homo sapiens)
TLE [nucleoplasm] (Homo sapiens)
TLE4 [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE4 tetramer [nucleoplasm] (Homo sapiens)
TLE4 [nucleoplasm] (Homo sapiens)
TLE recruits HDAC1 to WNT promoters (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE4 tetramer [nucleoplasm] (Homo sapiens)
TLE4 [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm] (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE4 tetramer [nucleoplasm] (Homo sapiens)
TLE4 [nucleoplasm] (Homo sapiens)
TLE tetramers bind TCF/LEF at WNT promoters (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE4 tetramer [nucleoplasm] (Homo sapiens)
TLE4 [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE4 tetramer [nucleoplasm] (Homo sapiens)
TLE4 [nucleoplasm] (Homo sapiens)
Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes (Homo sapiens)
'canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm] (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE4 tetramer [nucleoplasm] (Homo sapiens)
TLE4 [nucleoplasm] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
XIAP binds TLE (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE4 tetramer [nucleoplasm] (Homo sapiens)
TLE4 [nucleoplasm] (Homo sapiens)
TLE:XIAP [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE4 tetramer [nucleoplasm] (Homo sapiens)
TLE4 [nucleoplasm] (Homo sapiens)
XIAP monoubiquinates TLE (Homo sapiens)
TLE:XIAP [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE4 tetramer [nucleoplasm] (Homo sapiens)
TLE4 [nucleoplasm] (Homo sapiens)
beta-catenin is replaced by repression complexes at the promoter (Homo sapiens)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE4 tetramer [nucleoplasm] (Homo sapiens)
TLE4 [nucleoplasm] (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Homo sapiens)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE4 tetramer [nucleoplasm] (Homo sapiens)
TLE4 [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE4 tetramer [nucleoplasm] (Homo sapiens)
TLE4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q04727 TLE4
Gene Names
TLE4, GRG4, KIAA1261
Chain
chain:1-773
Reference Genes
BioGPS Gene:7091 TLE4
COSMIC (genes):TLE4 TLE4
CTD Gene:7091 TLE4
dbSNP Gene:7091 TLE4
ENSEMBL:ENSG00000106829 TLE4
ENSEMBL_homo_sapiens_GENE:ENSG00000106829.21 TLE4
HGNC:11840 TLE4
KEGG Gene (Homo sapiens):7091 TLE4
Monarch:7091 TLE4
NCBI Gene:7091 TLE4
OMIM:605132 TLE4
UCSC:Q04727 TLE4
Reference Transcript
RefSeq:NM_001282748.1 TLE4
RefSeq:NM_007005.4 TLE4
RefSeq:NM_001282749.1 TLE4
RefSeq:NM_001282753.1 TLE4
Other Identifiers
11719995_a_at
11719996_at
11719997_a_at
204872_PM_at
204872_at
216997_PM_x_at
216997_x_at
233575_PM_s_at
233575_s_at
235765_PM_at
235765_at
3176215
3176216
3176218
3176219
3176221
3176232
3176233
3176241
3176242
3176251
3176252
3176253
3176256
3176259
3176260
3176261
3176265
3176266
3176267
3176268
3176269
3176270
3176271
3176272
3176273
3176274
3176275
3211586
3211591
38364_at
40692_at
51042_i_at
51044_r_at
7091
8156060
A_23_P83094
A_23_P94494
GE53855
GE81709
GO:0000122
GO:0003682
GO:0003714
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0006351
GO:0006355
GO:0008150
GO:0016055
GO:0023052
GO:0043226
GO:0045892
GO:0090090
GO:0140110
GO:0140297
GO:1990830
GO:1990907
HMNXSV003005357
HMNXSV003057607
Hs.296039.0.A1_3p_at
Hs.83958.0.A1_3p_at
Hs.83958.0.A1_3p_x_at
Hs.83958.1.S1_3p_a_at
ILMN_1696704
ILMN_2103761
M99439_at
PH_hs_0005573
TC09002032.hg
g5921462_3p_at
Participates
as a member of
TLE [nucleoplasm] (Homo sapiens)
TLE [nucleoplasm] (Homo sapiens)
as a component of
TLE4 tetramer [nucleoplasm] (Homo sapiens)
Other forms of this molecule
Ub-TLE4 [nucleoplasm]
Inferred To
Tle4 [nucleoplasm]
(Mus musculus)
Tle4 [nucleoplasm]
(Rattus norvegicus)
gro [nucleoplasm]
(Drosophila melanogaster)
unc-37 [nucleoplasm]
(Caenorhabditis elegans)
tle4 [nucleoplasm]
(Xenopus tropicalis)
TLE4 [nucleoplasm]
(Bos taurus)
TLE4 [nucleoplasm]
(Canis familiaris)
TLE4 [nucleoplasm]
(Gallus gallus)
TLE4 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001269682.1
,
NP_001269678.1
,
NP_008936.2
,
NP_001269677.1
OpenTargets
ENSG00000106829
GeneCards
Q04727
HPA
ENSG00000106829-TLE4
Ensembl
ENSP00000265284
,
ENST00000265284
,
ENST00000376537
,
ENSP00000365720
,
ENST00000376552
,
ENSG00000106829
,
ENST00000376544
,
ENSP00000365735
,
ENSP00000365727
PRO
Q04727
Pharos - Targets
Q04727
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