Formation of CSL-NICD coactivator complex

Stable Identifier
R-HSA-212356
Type
Reaction [binding]
Species
Homo sapiens
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Mammalian CSL Coactivator Complexes: Upon activation of Notch signaling, cleavage of the transmembrane Notch receptor releases the Notch Intracellular Domain (NICD), which translocates to the nucleus, where it binds to CSL and displaces the corepressor complex from CSL (reviewed in Mumm, 2000 and Kovall, 2007). The resulting CSL-NICD "binary complex" then recruits an additional coactivator, Mastermind (Mam), to form a ternary complex. The ternary complex then recruits additional, more general coactivators, such as CREB Binding Protein (CBP), or the related p300 coactivator, and a number of Histone Acetytransferase (HAT) proteins, including GCN5 and PCAF (Fryer, 2002). There is evidence that Mam also can subsequently recruit specific kinases that phosphorylate NICD, to downregulate its function and turn off Notch signaling (Fryer, 2004).

Literature References
PubMed ID Title Journal Year
11112321 Notch signaling: from the outside in

Mumm, JS, Kopan, R

Dev Biol 2000
17157496 Structures of CSL, Notch and Mastermind proteins: piecing together an active transcription complex

Kovall, RA

Curr Opin Struct Biol 2007
15546612 Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

Fryer, CJ, White, JB, Jones, KA

Mol Cell 2004
12050117 Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex

Fryer, CJ, Lamar, E, Turbachova, I, Kintner, C, Jones, KA

Genes Dev 2002
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