Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin

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R-HSA-212252
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Reaction [omitted]
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Homo sapiens
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The core of the Polycomb Repressor Complex 2 (PRC2) contains EZH2, EED, SUV12, RpAp46, and RpAp48 (Kuzzmichev et al. 2002, Cao et al. 2002). PRC2 complexes at different sites in the genome contain the core subunits plus different accessory subunits. In Drosophila PRC2 is recruited to chromatin by specific DNA sequences. In vertebrates PRC2 appears to be recruited to chromatin through several mechanisms: some (about 20%) of noncoding RNAs tethered to the locus of origin recruit PRC2 via the RNA-binding activity of EZH2 (Zhao et al. 2008, Khalil et al. 2009), GC-rich sequence elements in DNA (Mendenhall et al. 2010) and poly(ADP-ribosyl) polymerase at sites of DNA damage (Chou et al. 2010) can also recruit polycomb components, The DNA-binding proteins JARID2, AEBP2, and YY1 recruit PRC2 (Pasini et al. 2010, Li et al. 2010, reviewed in Kim and Kim 2012). The EED subunit of PRC2 can bind existing trimethylated lysine-27 on histone H3 of PRC2 which may provide a mechanism for propagation of trimethylated lysine-27 during DNA replication (Xu et al. 2010).

Literature References
PubMed ID Title Journal Year
21170310 GC-rich sequence elements recruit PRC2 in mammalian ES cells

Mendenhall, EM, Koche, RP, Truong, T, Zhou, VW, Issac, B, Chi, AS, Ku, M, Bernstein, BE

PLoS Genet. 2010
20937877 A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

Chou, DM, Adamson, B, Dephoure, NE, Tan, X, Nottke, AC, Hurov, KE, Gygi, SP, Colaiácovo, MP, Elledge, SJ

Proc. Natl. Acad. Sci. U.S.A. 2010
19571010 Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

Khalil, AM, Guttman, M, Huarte, M, Garber, M, Raj, A, Rivea Morales, D, Thomas, K, Presser, A, Bernstein, BE, van Oudenaarden, A, Regev, A, Lander, ES, Rinn, JL

Proc. Natl. Acad. Sci. U.S.A. 2009
20123894 Jarid2 and PRC2, partners in regulating gene expression

Li, G, Margueron, R, Ku, M, Chambon, P, Bernstein, BE, Reinberg, D

Genes Dev. 2010
18974356 Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome

Zhao, J, Sun, BK, Erwin, JA, Song, JJ, Lee, JT

Science 2008
23431328 Noncoding RNA and Polycomb recruitment

Brockdorff, N

RNA 2013
20974918 Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)

Xu, C, Bian, C, Yang, W, Galka, M, Ouyang, H, Chen, C, Qiu, W, Liu, H, Jones, AE, MacKenzie, F, Pan, P, Li, SS, Wang, H, Min, J

Proc. Natl. Acad. Sci. U.S.A. 2010
20075857 JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

Pasini, D, Cloos, PA, Walfridsson, J, Olsson, L, Bukowski, JP, Johansen, JV, Bak, M, Tommerup, N, Rappsilber, J, Helin, K

Nature 2010
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