Cyclophosphamide is 4-hydroxylated by CYP2B6

Stable Identifier
R-HSA-211991
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen
ReviewStatus
5/5
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Cyclophosphamide is 4-hydroxylated by CYP2B6
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Cyclophosphamide (CPA) is an alkylating agent used in cancer chemotherapy and an immunosuppressant. CYP2B6 converts CPA to the active metabolite 4-hydroxy-CPA.

Literature References
PubMed ID Title Journal Year
12629583 Role of polymorphic human CYP2B6 in cyclophosphamide bioactivation

Lundgren, S, Griskevicius, L, Xie, HJ, Terelius, Y, Rane, A, Yasar, U, Hassan, M

Pharmacogenomics J 2003
Participants
Input
Output
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as an event of
Catalyst Activity

monooxygenase activity of Cytochrome P450 (CYP2B6 based) [endoplasmic reticulum membrane]

Physical Entity
Cytochrome P450 (CYP2B6 based) [endoplasmic reticulum membrane] (Homo sapiens)
Activity
monooxygenase activity (GO:0004497)
Orthologous Events
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Bos taurus)
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Canis familiaris)
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Danio rerio)
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Dictyostelium discoideum)
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Gallus gallus)
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Mus musculus)
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Rattus norvegicus)
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Sus scrofa)
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-02-08)
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