Long-chain 3-hydroxy fatty acids (3OHFAs) are omega-hydroxylated to form 3-hydroxydicarboxylic acid (3OHDCAs) precursors in human liver. These products may be implicated in pathological states where fatty acid mobilzation or impairment of mitochondrial fatty acid beta-oxidation increases 3-OHFA levels. CYP4A11, an orphan P450, has been shown to 18- and 16-hydroxylate 3-hydroxystearate and 3-hydroxypalmitate (3OH-PALM) respectively to omega-hydroxylated precursors; the latter is shown here (Dhar et al. 2008).
Sepkovic, DW, Hirani, V, Lasker, JM, Magnusson, RP, Dhar, M
monooxygenase activity of Cytochrome P450 (CYP4F11 based) [endoplasmic reticulum membrane]
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