CYP4F11 16-hydroxylates 3OH-PALM

Stable Identifier
R-HSA-211962
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Long-chain 3-hydroxy fatty acids (3OHFAs) are omega-hydroxylated to form 3-hydroxydicarboxylic acid (3OHDCAs) precursors in human liver. These products may be implicated in pathological states where fatty acid mobilzation or impairment of mitochondrial fatty acid beta-oxidation increases 3-OHFA levels. CYP4A11, an orphan P450, has been shown to 18- and 16-hydroxylate 3-hydroxystearate and 3-hydroxypalmitate (3OH-PALM) respectively to omega-hydroxylated precursors; the latter is shown here (Dhar et al. 2008).

Literature References
PubMed ID Title Journal Year
18065749 Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11

Dhar, M, Sepkovic, DW, Hirani, V, Magnusson, RP, Lasker, JM

J Lipid Res 2008
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Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP4F11 based) [endoplasmic reticulum membrane]
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Activity
Orthologous Events
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Created