Reactome | CYP4F11 16-hydroxylates 3OH-PALM

CYP4F11 16-hydroxylates 3OH-PALM

Stable Identifier

R-HSA-211962

Type

Reaction [transition]

Species

Homo sapiens

Compartment

smooth endoplasmic reticulum

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Long-chain 3-hydroxy fatty acids (3OHFAs) are omega-hydroxylated to form 3-hydroxydicarboxylic acid (3OHDCAs) precursors in human liver. These products may be implicated in pathological states where fatty acid mobilzation or impairment of mitochondrial fatty acid beta-oxidation increases 3-OHFA levels. CYP4A11, an orphan P450, has been shown to 18- and 16-hydroxylate 3-hydroxystearate and 3-hydroxypalmitate (3OH-PALM) respectively to omega-hydroxylated precursors; the latter is shown here (Dhar et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18065749	Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11 Dhar, M, Sepkovic, DW, Hirani, V, Magnusson, RP, Lasker, JM	J Lipid Res	2008