Reactome | CYP1B1 4-hydroxylates EST17b

CYP1B1 4-hydroxylates EST17b

Stable Identifier

R-HSA-211951

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

17beta-estradiol + O2 + reduced (NADPH--hemoprotein reductase) => 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)

ReviewStatus

5/5

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Cytochrome P450 1B1 (CYP1B1) can oxidise a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics as well as activating a range of procarcinogens. A specific substrate is the female sex hormone estradiol-17beta (EST17b) which is 4-hydroxylated to 4-hydroxyestradiol-17beta 4OH-EST17b) (Badawi et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11555828	Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol Badawi, AF, Cavalieri, EL, Rogan, EG	Metabolism	2001

Participants

Input

Output

Participates

as an event of

Endogenous sterols (Homo sapiens)

Catalyst Activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen of CYP1B1 [endoplasmic reticulum membrane]

Physical Entity

CYP1B1 [endoplasmic reticulum membrane] (Homo sapiens)

Activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709)

This event is regulated

Negatively by

Regulator

AHRR:ARNT [nucleoplasm] (Homo sapiens)

Positively by

Regulator

AHR:TCDD:ARNT [nucleoplasm] (Homo sapiens)

Orthologous Events