CYP24A1 24-hydroxylates CTL

Stable Identifier
Reaction [transition]
Homo sapiens
CYP24A1 catalyzes the initial step in the deactivation of the hormonally active form of vitamin D3
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Catabolic inactivation of the active, hormonal form of vitamin D3 (1,25-dihydroxyvitamin D3, calcitriol, CTL) is initially carried out by 24-hydroxylation, mediated by CYP24A1 (1,25-dihydroxyvitamin D3 24-hydroxylase). The product formed is eventually transformed to calcitroic acid (CTLA), the major water-soluble metabolite that can be excreted in bile.

Literature References
PubMed ID Title Journal Year
8679605 Human 25-hydroxyvitamin D3-24-hydroxylase, a multicatalytic enzyme

Beckman, MJ, DeLuca, HF, Yamada, S, Prahl, J, Tadikonda, P, Werner, E

Biochemistry 1996
17646648 Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone

Prosser, DE, Kaufmann, M, Byford, V, Jones, G, O'Leary, B

Proc Natl Acad Sci U S A 2007
11012668 Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24

Komai, K, Sawada, N, Ohyama, Y, Shiozawa, S, Sakaki, T, Yamada, S, Inouye, K, Yamamoto, K

Eur J Biochem 2000
as an event of
Catalyst Activity

1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity of CYP24A1 [mitochondrial inner membrane]

Orthologous Events
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