CYP24A1 24-hydroxylates CTL

Stable Identifier
R-HSA-211950
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
CYP24A1 catalyzes the initial step in the deactivation of the hormonally active form of vitamin D3
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Catabolic inactivation of the active, hormonal form of vitamin D3 (1,25-dihydroxyvitamin D3, calcitriol, CTL) is initially carried out by 24-hydroxylation, mediated by CYP24A1 (1,25-dihydroxyvitamin D3 24-hydroxylase). The product formed is eventually transformed to calcitroic acid (CTLA), the major water-soluble metabolite that can be excreted in bile.

Literature References
PubMed ID Title Journal Year
17646648 Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone

Prosser, DE, Kaufmann, M, O'Leary, B, Byford, V, Jones, G

Proc Natl Acad Sci U S A 2007
8679605 Human 25-hydroxyvitamin D3-24-hydroxylase, a multicatalytic enzyme

Beckman, MJ, Tadikonda, P, Werner, E, Prahl, J, Yamada, S, DeLuca, HF

Biochemistry 1996
11012668 Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24

Sakaki, T, Sawada, N, Komai, K, Shiozawa, S, Yamada, S, Yamamoto, K, Ohyama, Y, Inouye, K

Eur J Biochem 2000
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity of CYP24A1 [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
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Created
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