Reactome | CYP2C19 5-hydroxylates omeprazole

CYP2C19 5-hydroxylates omeprazole

Stable Identifier

R-HSA-211929

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

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Omeprazole is a potent long-acting inhibitor of gastric acid secretion by irreversible binding to the proton pump (H+,K+) ATPase in the gastric parietal cell. CYP2C19 is the major P450 which involved in 5-hydroxylation of omeprazole.

Literature References

PubMed ID	Title	Journal	Year
8647857	Identification of residues 99, 220, and 221 of human cytochrome P450 2C19 as key determinants of omeprazole activity Ibeanu, GC, Ghanayem, BI, Linko, P, Li, L, Pederson, LG, Goldstein, JA	J Biol Chem	1996