Omeprazole is a potent long-acting inhibitor of gastric acid secretion by irreversible binding to the proton pump (H+,K+) ATPase in the gastric parietal cell. CYP2C19 is the major P450 which involved in 5-hydroxylation of omeprazole.
Ibeanu, GC, Ghanayem, BI, Linko, P, Li, L, Pederson, LG, Goldstein, JA
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