CYP4F12 18-hydroxylates ARA

Stable Identifier
R-HSA-211904
Type
Reaction [transition]
Species
Homo sapiens
Compartment
smooth endoplasmic reticulum
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CYP4F12 18-hydroxylates ARA
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Human CYP4F12 is involved in metabolism of endogenous compounds such as inflammatory mediators (arachidonic acid and prostaglandin H2) as well as xenobiotics like terfenadine (an antihistaminic drug) (Bylund et al. 2001). The omega-hydroxylation of arachidonic acid (ARA) is shown here to form 18-hydroxyarachidonic acid (18OH-ARA aka 18-HETE).

Literature References
PubMed ID Title Journal Year
11162607 cDna cloning and expression of CYP4F12, a novel human cytochrome P450

Bylund, J, Bylund, M, Oliw, EH

Biochem Biophys Res Commun 2001
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP4F12 based) [endoplasmic reticulum membrane]
Physical Entity
Cytochrome P450 (CYP4F12 based) [endoplasmic reticulum membrane]
Activity
monooxygenase activity (0004497)
Orthologous Events
CYP4F12 18-hydroxylates ARA (Bos taurus)
CYP4F12 18-hydroxylates ARA (Danio rerio)
CYP4F12 18-hydroxylates ARA (Gallus gallus)
CYP4F12 18-hydroxylates ARA (Mus musculus)
CYP4F12 18-hydroxylates ARA (Rattus norvegicus)
CYP4F12 18-hydroxylates ARA (Sus scrofa)
CYP4F12 18-hydroxylates ARA (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-02-08)