Human CYP4F12 is involved in metabolism of endogenous compounds such as inflammatory mediators (arachidonic acid and prostaglandin H2) as well as xenobiotics like terfenadine (an antihistaminic drug) (Bylund et al. 2001). The omega-hydroxylation of arachidonic acid (ARA) is shown here to form 18-hydroxyarachidonic acid (18OH-ARA aka 18-HETE).
Oliw, EH, Bylund, J, Bylund, M
monooxygenase activity of Cytochrome P450 (CYP4F12 based) [endoplasmic reticulum membrane]
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