CYP3A7 can 6beta-hydroxylate testosterone

Stable Identifier
R-HSA-211882
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CYP3A7 can 6beta-hydroxylate testosterone
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CYP3A7 is only expressed in fetal liver and not in adults. It has lower biotransformation capability than other members of the CYP3A family such as 3A4 or 3A5 but possesses a similar broad specificity. CYP3A7 plays a major role in fetal steroid hydroxylation, an example being the 6beta-hydroxylation of testosterone.

Literature References
PubMed ID Title Journal Year
9644715 Steroid hydroxylation by human fetal CYP3A7 and human NADPH-cytochrome P450 reductase coexpressed in insect cells using baculovirus

Ohmori, S, Fujiki, N, Nakasa, H, Nakamura, H, Ishii, I, Itahashi, K, Kitada, M

Res Commun Mol Pathol Pharmacol 1998
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP3A7 based) [endoplasmic reticulum membrane]
Physical Entity
Cytochrome P450 (CYP3A7 based) [endoplasmic reticulum membrane]
Activity
monooxygenase activity (0004497)
Orthologous Events
CYP3A7 can 6beta-hydroxylate testosterone (Bos taurus)
CYP3A7 can 6beta-hydroxylate testosterone (Canis familiaris)
CYP3A7 can 6beta-hydroxylate testosterone (Danio rerio)
CYP3A7 can 6beta-hydroxylate testosterone (Gallus gallus)
CYP3A7 can 6beta-hydroxylate testosterone (Mus musculus)
CYP3A7 can 6beta-hydroxylate testosterone (Rattus norvegicus)
CYP3A7 can 6beta-hydroxylate testosterone (Sus scrofa)
CYP3A7 can 6beta-hydroxylate testosterone (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-02-08)