Reactome | CYP3A7 can 6beta-hydroxylate testosterone

CYP3A7 can 6beta-hydroxylate testosterone

Stable Identifier

R-HSA-211882

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

ReviewStatus

5/5

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CYP3A7 can 6beta-hydroxylate testosterone

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CYP3A7 is only expressed in fetal liver and not in adults. It has lower biotransformation capability than other members of the CYP3A family such as 3A4 or 3A5 but possesses a similar broad specificity. CYP3A7 plays a major role in fetal steroid hydroxylation, an example being the 6beta-hydroxylation of testosterone.

Literature References

PubMed ID	Title	Journal	Year
9644715	Steroid hydroxylation by human fetal CYP3A7 and human NADPH-cytochrome P450 reductase coexpressed in insect cells using baculovirus Nakasa, H, Nakamura, H, Itahashi, K, Ishii, I, Fujiki, N, Kitada, M, Ohmori, S	Res Commun Mol Pathol Pharmacol	1998