CYP3A7 can 6beta-hydroxylate testosterone

Stable Identifier
R-HSA-211882
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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CYP3A7 is only expressed in fetal liver and not in adults. It has lower biotransformation capability than other members of the CYP3A family such as 3A4 or 3A5 but possesses a similar broad specificity. CYP3A7 plays a major role in fetal steroid hydroxylation, an example being the 6beta-hydroxylation of testosterone.
Literature References
PubMed ID Title Journal Year
9644715 Steroid hydroxylation by human fetal CYP3A7 and human NADPH-cytochrome P450 reductase coexpressed in insect cells using baculovirus

Nakasa, H, Nakamura, H, Itahashi, K, Ishii, I, Fujiki, N, Kitada, M, Ohmori, S

Res Commun Mol Pathol Pharmacol 1998
Participants
Participates
Catalyst Activity

monooxygenase activity of Cytochrome P450 (CYP3A7 based) [endoplasmic reticulum membrane]

Orthologous Events
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