Reactome | Coumarin is 7-hydroxylated by CYP2A13

Coumarin is 7-hydroxylated by CYP2A13

Stable Identifier

R-HSA-211881

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen, smooth endoplasmic reticulum

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CYP2A13 can also 7-hydroxylate coumarin. It shares a 93.5% identity with CYP2A6 in the amino acid sequence but it is only about one-tenth as active as CYP2A6 in catalyzing coumarin 7-hydroxylation.

Literature References

PubMed ID	Title	Journal	Year
15196988	Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation He, XY, Shen, J, Hu, WY, Ding, X, Lu, AY, Hong, JY	Arch Biochem Biophys	2004