Regulation of PAK-2p34 activity by PS-GAP/RHG10

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R-HSA-211728
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Homo sapiens
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PS-GAP (RGH10) interacts specifically with caspase-activated PAK-2p34 reducing the ability of PAK-2p34 to induce cell death. This interaction inhibits the kinase activity of PAK-2p34 and changes the localization of PAK-2p34 from the nucleus to the perinuclear region (Koeppel et al., 2004).

Literature References
PubMed ID Title Journal Year
15471851 Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2

Koeppel, MA, McCarthy, CC, Moertl, E, Jakobi, R

J Biol Chem 2004
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