Regulation of PAK-2p34 activity by PS-GAP/RHG10

Stable Identifier
R-HSA-211728
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Regulation of PAK-2p34 activity by PS-GAP/RHG10
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PS-GAP (RGH10) interacts specifically with caspase-activated PAK-2p34 reducing the ability of PAK-2p34 to induce cell death. This interaction inhibits the kinase activity of PAK-2p34 and changes the localization of PAK-2p34 from the nucleus to the perinuclear region (Koeppel et al., 2004).
Literature References
PubMed ID Title Journal Year
15471851 Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2

Jakobi, R, Koeppel, MA, McCarthy, CC, Moertl, E

J Biol Chem 2004
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Event Information
Go Biological Process
negative regulation of apoptotic process (0043066)
Authored
Jakobi, R  (2008-02-05)
Reviewed
Chang, E  (2008-05-21)
Created
Matthews, L  (2008-02-08)
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