Proteolytic PAK-2p34 fragment translocates to the nucleus

Stable Identifier
R-HSA-211712
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nuclear envelope
ReviewStatus
5/5
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Proteolytic PAK-2p34 fragment translocates to the nucleus
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The subcellular localization of PAK-2 is controlled by nuclear localization and nuclear export signal motifs (Jakobi et al.,2003). The regulatory domain contains a nuclear export signal motif that prevents the nuclear accumulation of full-length PAK-2. The activating proteolytic cleavage disrupts the nuclear export signal in PAK-2 and removes most its regulatory domain. The resulting activated PAK-2p34 fragment contains a nuclear localization signal and translocates to and is retained in the nucleus (Jakobi et al.,2003).
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Inferred From
Proteolytic PAK-2p34 fragment translocates to the nucleus (Oryctolagus cuniculus)
Authored
Jakobi, R  (2008-02-05)
Reviewed
Chang, E  (2008-05-21)
Created
Matthews, L  (2008-02-08)
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