Cleavage of PAK-2 at 212

Stable Identifier
R-HSA-211651
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Cleavage of PAK-2 at 212
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p21-activated protein kinase (PAK-2), also known as gamma-PAK, is cleaved by caspase-3 during apoptosis and plays a role in regulating cell death. Cleavage produces two peptides; 1-212 containing most of the regulatory domain and 213-524 containing 34 amino acids of the regulatory domain as well as the catalytic domain (Walter et al., 1998). Proteolytic cleavage of PAK by caspase-3 creates the constitutively active PAK-2p34 fragment (Jakobi et al., 2003). Evidence for this reaction comes from experiments using both human and rabbit proteins.
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Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

Physical Entity
Caspase-3 [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Inferred From
Cleavage of PAK-2 at 212 (Oryctolagus cuniculus)
Authored
Jakobi, R  (2008-02-05)
Reviewed
Chang, E  (2008-05-21)
Created
Matthews, L  (2008-02-08)
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