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Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197
Stable Identifier
R-HSA-211583
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Stimulation of the cell death response by PAK-2p34 (Homo sapiens)
Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Inactive PAK-2 can be partially autophosphorylated in the regulatory region without being activated (Gatti et al. 1999).
Literature References
PubMed ID
Title
Journal
Year
16204230
Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141
Traugh, JA
,
Jung, JH
J Biol Chem
2005
Participants
Input
x 5
ATP [cytosol]
PAK2 [cytosol]
(Homo sapiens)
Output
x 5
ADP [cytosol]
p-5S-PAK2 [cytosol]
(Homo sapiens)
Participates
as an event of
Stimulation of the cell death response by PAK-2p34 (Homo sapiens)
Catalyst Activity
protein serine/threonine kinase activity of PAK2 [cytosol]
Physical Entity
PAK2 [cytosol]
(Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197 (Oryctolagus cuniculus)
Authored
Jakobi, R (2008-02-05)
Reviewed
Chang, E (2008-05-21)
Created
Matthews, L (2008-02-08)
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