Reactome | PKLR-2 [cytosol]

PKLR-2 [cytosol]

Stable Identifier

R-HSA-211388

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PKLR isozyme L, PKLR isoform 2, Pyruvate kinase, L isozyme, pyruvate kinase, liver and RBC, Red cell/liver pyruvate kinase

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Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Metabolism of carbohydrates (Homo sapiens)
  - Glucose metabolism (Homo sapiens)
    - Glycolysis (Homo sapiens)
      - phosphoenolpyruvate + ADP => pyruvate + ATP (Homo sapiens)
        
        pyruvate kinase tetramer [cytosol] (Homo sapiens)
        
        pyruvate kinase complex, liver and RBC [cytosol] (Homo sapiens)
        
        Pyruvate kinase, R/L type [cytosol] (Homo sapiens)
        
        PKLR-2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30613-2 PKLR

Gene Names

PKLR, PK1, PKL

Other Identifiers

0000510113

0005550215

0006620278

11730104_a_at

11730105_a_at

11740858_a_at

16694158

207858_PM_s_at

207858_s_at

210451_PM_at

210451_at

222078_PM_at

222078_at

2437364

2437365

2437366

2437367

2437368

2437369

2437370

2437371

2437372

2437373

2437374

2437375

2437376

2437377

2437378

2437379

2437380

37077_at

5313

7920744

92008_s_at

A_23_P201022

A_24_P325533

D10326_s_at

GE60479

GO:0000166

GO:0000287

GO:0001666

GO:0003824

GO:0004743

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005829

GO:0005975

GO:0006091

GO:0006096

GO:0006754

GO:0007584

GO:0008152

GO:0009408

GO:0009749

GO:0010038

GO:0010226

GO:0016301

GO:0016310

GO:0016740

GO:0030955

GO:0032869

GO:0033198

GO:0042866

GO:0043226

GO:0046872

GO:0048029

GO:0051591

GO:0055086

GO:0070062

GO:0071872

GO:1901135

HMNXSV003035410

Hs.284171.0.A1_3p_at

ILMN_1723644

ILMN_1725172

ILMN_1777031

ILMN_2279397

ILMN_2380561

M15465_s_at

PH_hs_0005223

TC01003312.hg

g10835120_3p_a_at

g189995_3p_at

Participates

as an output of

HNF1A-dependent synthesis of the L isoform of PKLR protein (Homo sapiens)

as a component of

pyruvate kinase, liver [cytosol] (Homo sapiens)

as a member of

Pyruvate kinase, R/L type [cytosol] (Homo sapiens)

Inferred To

Dmel\CG7362 [cytosol] (Drosophila melanogaster)

PKLR-2 [cytosol] (Canis familiaris)

PKLR-2 [cytosol] (Danio rerio)

PKLR-2 [cytosol] (Dictyostelium discoideum)

PKLR-2 [cytosol] (Drosophila melanogaster)

PKLR-2 [cytosol] (Mus musculus)

PKLR-2 [cytosol] (Plasmodium falciparum)

PKLR-2 [cytosol] (Rattus norvegicus)

PKLR-2 [cytosol] (Saccharomyces cerevisiae)

PKLR-2 [cytosol] (Schizosaccharomyces pombe)

Homologues of PKLR-2 [cytosol] (Caenorhabditis elegans)

Homologues of PKLR-2 [cytosol] (Danio rerio)

Homologues of PKLR-2 [cytosol] (Drosophila melanogaster)

Homologues of PKLR-2 [cytosol] (Plasmodium falciparum)

Homologues of PKLR-2 [cytosol] (Saccharomyces cerevisiae)

Dmel\CG2964 [cytosol] (Drosophila melanogaster)

PKLR [cytosol] (Bos taurus)

PKLR [cytosol] (Sus scrofa)

pyk-2 [cytosol] (Caenorhabditis elegans)

Dmel\CG12229 [cytosol] (Drosophila melanogaster)

pklr [cytosol] (Xenopus tropicalis)

Dmel\CG7069 [cytosol] (Drosophila melanogaster)

pyk-1 [cytosol] (Caenorhabditis elegans)

Dmel\CG11249 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_870986.1, NP_000289.1

Guide to Pharmacology - Targets

3007

OpenTargets

ENSG00000143627

GeneCards

P30613

HPA

ENSG00000143627-PKLR

ZINC target

P30613

Ensembl

ENSG00000143627, ENST00000571194, ENSP00000376214, ENSP00000339933, ENST00000342741, ENSP00000459921, ENSG00000262785, ENSP00000461487, ENST00000392414, ENST00000572740

PRO

P30613

Pharos - Targets

P30613

Orphanet

15101

PDB

6NN8, 2VGF, 7QDN, 6NN7, 6NN5, 6NN4, 4IP7, 2VGG, 2VGB, 4IMA, 2VGI