Reactome | PKLR-2 [cytosol]

PKLR-2 [cytosol]

Stable Identifier

R-HSA-211388

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PKLR isozyme L, PKLR isoform 2, Pyruvate kinase, L isozyme, pyruvate kinase, liver and RBC, Red cell/liver pyruvate kinase

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Metabolism (Homo sapiens)

- Metabolism of carbohydrates (Homo sapiens)
  - Glucose metabolism (Homo sapiens)
    - Glycolysis (Homo sapiens)
      - phosphoenolpyruvate + ADP => pyruvate + ATP (Homo sapiens)
        
        pyruvate kinase tetramer [cytosol] (Homo sapiens)
        
        pyruvate kinase complex, liver and RBC [cytosol] (Homo sapiens)
        
        Pyruvate kinase, R/L type [cytosol] (Homo sapiens)
        
        PKLR-2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30613-2 PKLR

Gene Names

PKLR, PK1, PKL

Other Identifiers

0000510113

00010+2.7.1.40

0005550215

0006620278

00230+2.7.1.40

00620+2.7.1.40

11730104_a_at

11730105_a_at

11740858_a_at

16694158

207858_s_at

210451_at

222078_at

2437364

2437365

2437366

2437367

2437368

2437369

2437370

2437371

2437372

2437373

2437374

2437375

2437376

2437377

2437378

2437379

2437380

2VGB

2VGF

2VGG

2VGI

34376

34378

37077_at

4IMA

4IP7

5313

6653

7920744

92008_s_at

A0A0G2JLC7

A_23_P201022

A_24_P325533

AAA60104

AAB26262

AAH25737

AAP69527

AB015983

AY316591

BAA02515

BAA31706

BC025737

CAB034376

CAB034378

CCDS1109

CCDS44240

D10326_s_at

D13243

ENSG00000143627

ENSG00000262785

ENSP00000339933

ENSP00000376214

ENSP00000459921

ENSP00000461487

ENST00000342741

ENST00000342741.6

ENST00000392414

ENST00000392414.7

ENST00000571194

ENST00000572740

EntrezGene:5313

EntrezGene:PKLR

F8W6W2

g10835120_3p_a_at

g189995_3p_at

GE60479

GO:0000166

GO:0000287

GO:0001666

GO:0003674

GO:0003824

GO:0004743

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0005975

GO:0006091

GO:0006096

GO:0006754

GO:0006950

GO:0007584

GO:0008150

GO:0008152

GO:0009056

GO:0009058

GO:0009408

GO:0009749

GO:0010038

GO:0010226

GO:0016301

GO:0016310

GO:0016740

GO:0030955

GO:0032869

GO:0033198

GO:0034641

GO:0042866

GO:0043167

GO:0043226

GO:0044281

GO:0046872

GO:0051591

GO:0061621

GO:0070062

GO:0071872

HGNC:9020

HPA006653

Hs.284171.0.A1_3p_at

ILMN_1723644

ILMN_1725172

ILMN_1777031

ILMN_2279397

ILMN_2380561

IPR001697

IPR011037

IPR015793

IPR015795

IPR015806

IPR015813

IPR018209

IPR036918

IPR040442

LRG_1136

M15465

M15465_s_at

MIM:102900

MIM:266200

MIM:609712

NM_000298

NM_181871

NP_000289

NP_870986

PF00224

PF02887

PH_hs_0005223

PKLR

PKLR-201

PKLR-202

PKLR-204

PKLR-205

PR01050

S60712

TC01003312.hg

UPI0000001292

UPI000002ACFF

XM_006711386

XM_011509640

XM_017001493

XP_006711449

XP_011507942

XP_016856982

Participant Of

output

HNF1A-dependent synthesis of the L isoform of PKLR protein

hasMember

Pyruvate kinase, R/L type [cytosol]

Inferred To

PKLR-2 [cytosol] (Bos taurus)

PKLR-2 [cytosol] (Caenorhabditis elegans)

PKLR-2 [cytosol] (Danio rerio)

PKLR-2 [cytosol] (Dictyostelium discoideum)

PKLR-2 [cytosol] (Drosophila melanogaster)

PKLR-2 [cytosol] (Mus musculus)

PKLR-2 [cytosol] (Plasmodium falciparum)

PKLR-2 [cytosol] (Rattus norvegicus)

PKLR-2 [cytosol] (Saccharomyces cerevisiae)

PKLR-2 [cytosol] (Schizosaccharomyces pombe)

PKLR-2 [cytosol] (Sus scrofa)

PKLR-2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_000289.1, NP_870986.1

OpenTargets

ENSG00000143627

GeneCards

P30613

ZINC target

P30613

PRO

P30613

Orphanet

15101

HMDB Protein

HMDBP00765

PDB

2VGB, 2VGG, 2VGF, 6NN5, 2VGI, 6NN8, 4IP7, 6NN7, 4IMA, 6NN4