Reactome | PKLR-2 [cytosol]

PKLR-2 [cytosol]

Stable Identifier

R-HSA-211388

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PKLR isozyme L, PKLR isoform 2, Pyruvate kinase, L isozyme, pyruvate kinase, liver and RBC, Red cell/liver pyruvate kinase

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Metabolism (Homo sapiens)

- Metabolism of carbohydrates (Homo sapiens)
  - Glucose metabolism (Homo sapiens)
    - Glycolysis (Homo sapiens)
      - phosphoenolpyruvate + ADP => pyruvate + ATP (Homo sapiens)
        
        pyruvate kinase tetramer [cytosol] (Homo sapiens)
        
        pyruvate kinase complex, liver and RBC [cytosol] (Homo sapiens)
        
        Pyruvate kinase, R/L type [cytosol] (Homo sapiens)
        
        PKLR-2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30613-2 PKLR

Gene Names

PKLR, PK1, PKL

Other Identifiers

0000510113

0005550215

0006620278

11730104_a_at

11730105_a_at

11740858_a_at

16694158

207858_s_at

210451_at

222078_at

2437364

2437365

2437366

2437367

2437368

2437369

2437370

2437371

2437372

2437373

2437374

2437375

2437376

2437377

2437378

2437379

2437380

37077_at

5313

7920744

92008_s_at

A_23_P201022

A_24_P325533

D10326_s_at

GE60479

GO:0000166

GO:0000287

GO:0001666

GO:0003674

GO:0003824

GO:0004743

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005829

GO:0005975

GO:0006091

GO:0006096

GO:0006754

GO:0006950

GO:0007584

GO:0008150

GO:0008152

GO:0009056

GO:0009058

GO:0009408

GO:0009749

GO:0010038

GO:0010226

GO:0016301

GO:0016310

GO:0016740

GO:0030955

GO:0032869

GO:0033198

GO:0034641

GO:0042866

GO:0043167

GO:0043226

GO:0044281

GO:0046872

GO:0051591

GO:0061621

GO:0070062

GO:0071872

Hs.284171.0.A1_3p_at

ILMN_1723644

ILMN_1725172

ILMN_1777031

ILMN_2279397

ILMN_2380561

M15465_s_at

PH_hs_0005223

TC01003312.hg

g10835120_3p_a_at

g189995_3p_at

Participant Of

output

HNF1A-dependent synthesis of the L isoform of PKLR protein

hasMember

Pyruvate kinase, R/L type [cytosol]

Inferred To

pyk1 [cytosol] (Schizosaccharomyces pombe)

PKLR-2 [cytosol] (Plasmodium falciparum)

Pklr [cytosol] (Mus musculus)

Pklr [cytosol] (Rattus norvegicus)

PKLR [cytosol] (Bos taurus)

PKLR [cytosol] (Sus scrofa)

pyk [cytosol] (Dictyostelium discoideum)

pyk-2 [cytosol] (Caenorhabditis elegans)

CDC19 [cytosol] (Saccharomyces cerevisiae)

pklr [cytosol] (Danio rerio)

adcy4 [cytosol] (Xenopus tropicalis)

PyK [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_870986.1, NP_000289.1

OpenTargets

ENSG00000143627

GeneCards

P30613

HPA

ENSG00000143627-PKLR

ZINC target

P30613

Ensembl

ENSG00000143627, ENST00000571194, ENSP00000376214, ENSP00000339933, ENST00000342741, ENSP00000459921, ENSG00000262785, ENST00000392414, ENSP00000461487, ENST00000572740

PRO

P30613

Orphanet

15101

HMDB Protein

HMDBP00765

PDB

2VGB, 2VGI, 4IP7, 6NN8, 2VGF, 6NN5, 4IMA, 6NN4, 6NN7, 2VGG