Association of DFF40 with chromatin

Stable Identifier
R-HSA-211239
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Direct interactions between the histone H1 C-terminal domain and DFF40/CAD possibly target the nuclease to chromatin linker DNA promoting the linker DNA cleavage during the terminal stages of apoptosis (Widlak et al., 2005). Noteworthy, it has been reported that DFF40/DFF45 complexes could also associate with chromatin and be activated with caspase-3 in DNA-bound state (Korn et al., 2005).
Literature References
PubMed ID Title Journal Year
15910001 The histone H1 C-terminal domain binds to the apoptotic nuclease, DNA fragmentation factor (DFF40/CAD) and stimulates DNA cleavage

Lu, X, Kalinowska, M, Hansen, JC, Widlak, P, Parseghian, MH, Garrard, WT

Biochemistry 2005
10318789 Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1

Garrard, W, Liu, X, Wang, X, Widlak, P, Zou, H

J Biol Chem 1999
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