Reactome | Association of DFF40 with chromatin

Association of DFF40 with chromatin

Stable Identifier

R-HSA-211239

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Direct interactions between the histone H1 C-terminal domain and DFF40/CAD possibly target the nuclease to chromatin linker DNA promoting the linker DNA cleavage during the terminal stages of apoptosis (Widlak et al., 2005). Noteworthy, it has been reported that DFF40/DFF45 complexes could also associate with chromatin and be activated with caspase-3 in DNA-bound state (Korn et al., 2005).

Literature References

PubMed ID	Title	Journal	Year
15910001	The histone H1 C-terminal domain binds to the apoptotic nuclease, DNA fragmentation factor (DFF40/CAD) and stimulates DNA cleavage Lu, X, Kalinowska, M, Hansen, JC, Widlak, P, Parseghian, MH, Garrard, WT	Biochemistry	2005
10318789	Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1 Garrard, W, Liu, X, Wang, X, Widlak, P, Zou, H	J Biol Chem	1999