Association of DFF40 with DFF45

Stable Identifier
R-HSA-211224
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Association of DFF40 with DFF45
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DNA Fragmentation Factor (DFF), is a heterodimer of 40 kDa (DFF40) and 45 kDa (DFF45) subunits (Liu et al., 1997). DFF45 (ICAD) appears to act as a chaperone for DFF40 (CAD) during its synthesis, remaining complexed with it to inhibit its DNase activity (Enari et al., 1998). The complex could exist as: a DFF40:DFF45 heterodimer, a (DFF40:DFF45)2 heterotetramer or a (DFF40:DFF40:DFF45:DFF45) heterotetramer (Lechardeur et al., 2005).
Literature References
PubMed ID Title Journal Year
9108473 DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

Liu, X, Slaughter, C, Wang, X, Zou, H

Cell 1997
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Orthologous Events
Association of DFF40 with DFF45 (Bos taurus)
Association of DFF40 with DFF45 (Canis familiaris)
Association of DFF40 with DFF45 (Danio rerio)
Association of DFF40 with DFF45 (Drosophila melanogaster)
Association of DFF40 with DFF45 (Gallus gallus)
Association of DFF40 with DFF45 (Mus musculus)
Association of DFF40 with DFF45 (Rattus norvegicus)
Association of DFF40 with DFF45 (Sus scrofa)
Association of DFF40 with DFF45 (Xenopus tropicalis)
Authored
Matthews, L  (2008-01-29)
Reviewed
Widlak, P  (2008-05-08)
Created
Matthews, L  (2008-01-29)
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