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CYP2C9 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-211017
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Cytochrome P450 2C9, CPC9_HUMAN
Locations in the PathwayBrowser
Expand all
Drug ADME (Homo sapiens)
Aspirin ADME (Homo sapiens)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Homo sapiens)
CYP2,3 cytochromes [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Homo sapiens)
CYP2,3 cytochromes [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Xenobiotics (Homo sapiens)
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Homo sapiens)
Cytochrome P450 (CYP2C18 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C19 5-hydroxylates omeprazole (Homo sapiens)
Cytochrome P450 (CYP2C19 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Homo sapiens)
Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Homo sapiens)
Cytochrome P450 (CYP2C9 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2D6 4-hydroxylates debrisoquine (Homo sapiens)
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2E1 reactions (Homo sapiens)
Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
Benzene is hydroxylated to phenol (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
Dehalogenation of carbon tetrachloride to form a free radical (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
MEOS oxidizes ethanol to acetaldehyde (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
Vinyl chloride is oxidized to 2-Chloroethylene oxide (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2F1 dehydrogenates 3-methylindole (Homo sapiens)
Cytochrome P450 (CYP2F1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
Coumarin is 7-hydroxylated by CYP2A13 (Homo sapiens)
Cytochrome P450 (CYP2A13 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
Cyclophosphamide is 4-hydroxylated by CYP2B6 (Homo sapiens)
Cytochrome P450 (CYP2B6 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
O-atom dealkylation of dextromethorphan (Homo sapiens)
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Biosynthesis of DHA-derived SPMs (Homo sapiens)
Biosynthesis of maresins (Homo sapiens)
Biosynthesis of maresin-like SPMs (Homo sapiens)
CYPs hydroxylate DHA to 14(R)-HDHA (Homo sapiens)
CYP1A2,2C8,2C9,2D6,2E1,3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonic acid metabolism (Homo sapiens)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (Homo sapiens)
Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Homo sapiens)
CYP(2) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Homo sapiens)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Homo sapiens)
CYP(5) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2C9 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11712 CYP2C9
Gene Names
CYP2C9, CYP2C10
Chain
chain:1-490
Reference Genes
BioGPS Gene:1559 CYP2C9
COSMIC (genes):CYP2C9 CYP2C9
CTD Gene:1559 CYP2C9
dbSNP Gene:1559 CYP2C9
ENSEMBL:ENSG00000138109 CYP2C9
ENSEMBL:ENSG00000138109.11 CYP2C9
HGNC:2623 CYP2C9
KEGG Gene (Homo sapiens):1559 CYP2C9
Monarch:1559 CYP2C9
NCBI Gene:1559 CYP2C9
OMIM:601130 CYP2C9
Reference Transcript
RefSeq:XM_017015758.1 CYP2C9
RefSeq:NM_000771.3 CYP2C9
Other Identifiers
11727471_a_at
11727472_x_at
11760391_at
11762721_x_at
1455_f_at
1559
16707757
214421_3p_x_at
214421_PM_x_at
214421_x_at
216025_3p_x_at
216025_PM_x_at
216025_x_at
216661_PM_x_at
216661_x_at
217558_PM_at
217558_at
220017_3p_x_at
220017_PM_x_at
220017_x_at
3259003
3259022
3259023
3259024
3259028
3259030
3259031
3259035
3259037
3259041
3259042
3259043
3259045
3259046
3259048
3259049
3259050
3259051
3259052
7929487
A_14_P103802
A_23_P12767
GE58011
GO:0003824
GO:0004497
GO:0005506
GO:0005737
GO:0005783
GO:0005789
GO:0005886
GO:0006629
GO:0006805
GO:0008202
GO:0008203
GO:0008210
GO:0008392
GO:0008395
GO:0008404
GO:0008405
GO:0016020
GO:0016098
GO:0016491
GO:0016705
GO:0016712
GO:0018675
GO:0018676
GO:0019369
GO:0019373
GO:0019627
GO:0020037
GO:0032787
GO:0034875
GO:0042178
GO:0042759
GO:0043226
GO:0043231
GO:0043603
GO:0046456
GO:0046872
GO:0052741
GO:0070330
GO:0070989
GO:0071941
GO:0097267
HMNXSV003011253
Hs.167529.1.S1_3p_a_at
Hs.167529.2.S1_3p_a_at
Hs.167529.2.S1_3p_x_at
Hs.167529.3.S1_3p_a_at
Hs.167529.3.S1_3p_x_at
Hs.282639.0.S1_3p_at
ILMN_1670652
M61855_at
PH_hs_0033258
TC10000675.hg
g13699817_3p_a_at
g13699817_3p_x_at
Participates
as a member of
CYP1A2,2C8,2C9,2D6,2E1,3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP(5) [endoplasmic reticulum membrane] (Homo sapiens)
CYP(2) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2,3 cytochromes [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2C9 based) [endoplasmic reticulum membrane] (Homo sapiens)
as a candidate of
Cytochrome P450 (CYP2C19 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2B6 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2A13 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2C18 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2F1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2C8 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Bos taurus)
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
Homologues of CYP2C19 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
panx3 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
CYP2C19 [endoplasmic reticulum membrane]
(Bos taurus)
CYP2C19 [endoplasmic reticulum membrane]
(Danio rerio)
CYP2C19 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
CYP2C19 [endoplasmic reticulum membrane]
(Gallus gallus)
CYP2C19 [endoplasmic reticulum membrane]
(Mus musculus)
CYP2C19 [endoplasmic reticulum membrane]
(Sus scrofa)
CYP2C19 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000762.2
,
XP_016871247.1
ZINC - World Drugs
CP2C9_HUMAN
Guide to Pharmacology - Targets
1326
OpenTargets
ENSG00000138109
ZINC - FDA approved
CP2C9_HUMAN
ZINC - Substances
CP2C9_HUMAN
ZINC - Biogenic
CP2C9_HUMAN
ZINC target
P11712
PRO
P11712
PDB
5XXI
,
1OG2
,
5X23
,
5K7K
,
1R9O
,
5X24
,
5A5I
,
5W0C
,
5A5J
,
1OG5
,
7RL2
,
6VLT
,
4NZ2
ZINC - Investigational
CP2C9_HUMAN
ZINC - Metabolites
CP2C9_HUMAN
IntEnz
1.14.14.52
GeneCards
P11712
HPA
ENSG00000138109-CYP2C9
Ensembl
ENSG00000138109
,
ENST00000461906
,
ENST00000260682
,
ENSP00000260682
,
ENSP00000495649
Pharos - Targets
P11712
ZINC - Predictions - Purchasable
CP2C9_HUMAN
Orphanet
19452
HMDB Protein
HMDBP01036
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