Gene Silencing by RNA

Stable Identifier
R-HSA-211000
Type
Pathway
Species
Homo sapiens
Compartment
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In this module, the biology of various types of regulatory non-coding RNAs are described. Biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs (miRNAs) are annotated. Biogenesis of PIWI-interacting small RNAs (piRNAs) and tRNA-derived small RNAs (tsRNAs) are also annotated.

Literature References
PubMed ID Title Journal Year
16510870 Control of translation and mRNA degradation by miRNAs and siRNAs

Liu, J, Hannon, GJ, Parker, R, Valencia-Sanchez, MA

Genes Dev 2006
15741316 Perspective: machines for RNAi

Tomari, Y, Zamore, PD

Genes Dev 2005
25565029 From guide to target: molecular insights into eukaryotic RNA-interference machinery

Joshua-Tor, L, Ipsaro, JJ

Nat. Struct. Mol. Biol. 2015
19239886 Origins and Mechanisms of miRNAs and siRNAs

Carthew, RW, Sontheimer, EJ

Cell 2009
21755468 microRNA Biogenesis and Function : An overview

Ketting, RF

Adv Exp Med Biol 2011
19165215 Biogenesis of small RNAs in animals

Han, J, Kim, VN, Siomi, MC

Nat Rev Mol Cell Biol 2009
17560368 Argonaute proteins: mediators of RNA silencing

Peters, L, Meister, G

Mol Cell 2007
19412884 Common themes in siRNA-mediated epigenetic silencing pathways

Verdel, A, Vavasseur, A, Touat-Todeschini, L, Le Gorrec, M

Int J Dev Biol 2009
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Orthologous Events
Cross References
GlyCosmos
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