Gene Silencing by RNA

Stable Identifier
Homo sapiens
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In this module, the biology of various types of regulatory non-coding RNAs are described. Biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs (miRNAs) are annotated. Biogenesis of PIWI-interacting small RNAs (piRNAs) and tRNA-derived small RNAs (tsRNAs) are also annotated.

Literature References
PubMed ID Title Journal Year
15741316 Perspective: machines for RNAi

Tomari, Y, Zamore, PD

Genes Dev 2005
16510870 Control of translation and mRNA degradation by miRNAs and siRNAs

Valencia-Sanchez, MA, Liu, J, Hannon, GJ, Parker, R

Genes Dev 2006
25565029 From guide to target: molecular insights into eukaryotic RNA-interference machinery

Ipsaro, JJ, Joshua-Tor, L

Nat. Struct. Mol. Biol. 2015
19239886 Origins and Mechanisms of miRNAs and siRNAs

Carthew, RW, Sontheimer, EJ

Cell 2009
21755468 microRNA Biogenesis and Function : An overview

Ketting, RF

Adv Exp Med Biol 2011
19165215 Biogenesis of small RNAs in animals

Kim, VN, Han, J, Siomi, MC

Nat Rev Mol Cell Biol 2009
17560368 Argonaute proteins: mediators of RNA silencing

Peters, L, Meister, G

Mol Cell 2007
19412884 Common themes in siRNA-mediated epigenetic silencing pathways

Verdel, A, Vavasseur, A, Le Gorrec, M, Touat-Todeschini, L

Int J Dev Biol 2009
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