Reactome | Gene Silencing by RNA

Gene Silencing by RNA

Stable Identifier

R-HSA-211000

Type

Pathway

Species

Homo sapiens

Compartment

nucleoplasm, nuclear envelope, cytosol

ReviewStatus

5/5

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In this module, the biology of various types of regulatory non-coding RNAs are described. Biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs (miRNAs) are annotated. Biogenesis of PIWI-interacting small RNAs (piRNAs) and tRNA-derived small RNAs (tsRNAs) are also annotated.

Literature References

PubMed ID	Title	Journal	Year
16510870	Control of translation and mRNA degradation by miRNAs and siRNAs Liu, J, Hannon, GJ, Parker, R, Valencia-Sanchez, MA	Genes Dev	2006
15741316	Perspective: machines for RNAi Tomari, Y, Zamore, PD	Genes Dev	2005
25565029	From guide to target: molecular insights into eukaryotic RNA-interference machinery Joshua-Tor, L, Ipsaro, JJ	Nat. Struct. Mol. Biol.	2015
19239886	Origins and Mechanisms of miRNAs and siRNAs Carthew, RW, Sontheimer, EJ	Cell	2009
21755468	microRNA Biogenesis and Function : An overview Ketting, RF	Adv Exp Med Biol	2011
19165215	Biogenesis of small RNAs in animals Han, J, Kim, VN, Siomi, MC	Nat Rev Mol Cell Biol	2009
17560368	Argonaute proteins: mediators of RNA silencing Peters, L, Meister, G	Mol Cell	2007
19412884	Common themes in siRNA-mediated epigenetic silencing pathways Verdel, A, Vavasseur, A, Touat-Todeschini, L, Le Gorrec, M	Int J Dev Biol	2009