Reactome | Gene Silencing by RNA

Gene Silencing by RNA

Stable Identifier

R-HSA-211000

Type

Pathway

Species

Homo sapiens

Compartment

nucleoplasm, nuclear envelope, cytosol

ReviewStatus

5/5

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In this module, the biology of various types of regulatory non-coding RNAs are described. Biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs (miRNAs) are annotated. Biogenesis of PIWI-interacting small RNAs (piRNAs) and tRNA-derived small RNAs (tsRNAs) are also annotated.

Literature References

PubMed ID	Title	Journal	Year
19412884	Common themes in siRNA-mediated epigenetic silencing pathways Verdel, A, Vavasseur, A, Touat-Todeschini, L, Le Gorrec, M	Int J Dev Biol	2009
17560368	Argonaute proteins: mediators of RNA silencing Peters, L, Meister, G	Mol Cell	2007
19165215	Biogenesis of small RNAs in animals Han, J, Kim, VN, Siomi, MC	Nat Rev Mol Cell Biol	2009
21755468	microRNA Biogenesis and Function : An overview Ketting, RF	Adv Exp Med Biol	2011
19239886	Origins and Mechanisms of miRNAs and siRNAs Carthew, RW, Sontheimer, EJ	Cell	2009
25565029	From guide to target: molecular insights into eukaryotic RNA-interference machinery Joshua-Tor, L, Ipsaro, JJ	Nat. Struct. Mol. Biol.	2015
15741316	Perspective: machines for RNAi Tomari, Y, Zamore, PD	Genes Dev	2005
16510870	Control of translation and mRNA degradation by miRNAs and siRNAs Liu, J, Hannon, GJ, Parker, R, Valencia-Sanchez, MA	Genes Dev	2006