NEUROG3-dependent synthesis of NKX2-2

Stable Identifier
R-HSA-210921
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NEUROG3-dependent synthesis of NKX2-2
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The NKX2-2 gene is transcribed, its mRNA is translated, and the protein product is transported to the nucleus. NKX2-2 transcription requires the activity of the NEUROG3 transcription factor (Heremans et al. 2002; Mellitzer et al. 2006).
Literature References
PubMed ID Title Journal Year
16511571 IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas

Mellitzer, G, Lan, M, Mansouri, A, Lee, J, Lenne-Samuel, N, Luco, RF, Gradwohl, G, Bonne, S, Van De Casteele, M, Ferrer, J, Collombat, P, Pipeleers, D, Heimberg, H, Nielsen, FC

EMBO J 2006
12403815 Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3

Serup, P, Madsen, OD, Gradwohl, G, Van De Casteele, M, Pipeleers, D, in't Veld, P, Heremans, Y, Heimberg, H

J Cell Biol 2002
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NEUROG3 [nucleoplasm] (Homo sapiens)
Authored
Tello-Ruiz, MK  (2008-05-24)
Ferrer, J  (2008-05-24)
Reviewed
Jensen, J  (2008-05-13)
Created
D'Eustachio, P  (2008-01-18)
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