NEUROG3-dependent synthesis of NKX2-2

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R-HSA-210921
Type
Reaction [omitted]
Species
Homo sapiens
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The NKX2-2 gene is transcribed, its mRNA is translated, and the protein product is transported to the nucleus. NKX2-2 transcription requires the activity of the NEUROG3 transcription factor (Heremans et al. 2002; Mellitzer et al. 2006).

Literature References
PubMed ID Title Journal Year
12403815 Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3

Heremans, Y, Van De Casteele, M, in't Veld, P, Gradwohl, G, Serup, P, Madsen, OD, Pipeleers, D, Heimberg, H

J Cell Biol 2002
16511571 IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas

Mellitzer, G, Bonne, S, Luco, RF, Van De Casteele, M, Lenne-Samuel, N, Collombat, P, Mansouri, A, Lee, J, Lan, M, Pipeleers, D, Nielsen, FC, Ferrer, J, Gradwohl, G, Heimberg, H

EMBO J 2006
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