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HES1 [nucleoplasm]
Stable Identifier
R-HSA-210825
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Hairy and enhancer of split 1, Transcription factor HES-1
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Regulation of beta-cell development (Homo sapiens)
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells (Homo sapiens)
HNF6-dependent synthesis of NEUROG3 protein during morphogenesis (Homo sapiens)
HES1 [nucleoplasm] (Homo sapiens)
NOTCH1 stimulates HES1 transcription (Homo sapiens)
HES1 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
NOTCH1 PEST domain mutants stimulate HES1 transcription (Homo sapiens)
HES1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
NOTCH1 PEST domain mutants stimulate HES1 transcription (Homo sapiens)
HES1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
RUNX2 regulates bone development (Homo sapiens)
RUNX2 regulates osteoblast differentiation (Homo sapiens)
RUNX2 binds HEY1,HEY2,HES1 (Homo sapiens)
HEY1,HEY2,HES1 [nucleoplasm] (Homo sapiens)
HES1 [nucleoplasm] (Homo sapiens)
RUNX2:HEY1,HEY2,HES1 [nucleoplasm] (Homo sapiens)
HEY1,HEY2,HES1 [nucleoplasm] (Homo sapiens)
HES1 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
RUNX3 regulates NOTCH signaling (Homo sapiens)
HES1 gene transcription is inhibited by RUNX3 (Homo sapiens)
HES1 [nucleoplasm] (Homo sapiens)
NOTCH1 stimulates HES1 transcription (Homo sapiens)
HES1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
HES1 binds TLE (Homo sapiens)
HES1 [nucleoplasm] (Homo sapiens)
HES1:TLE [nucleoplasm] (Homo sapiens)
HES1 [nucleoplasm] (Homo sapiens)
NOTCH1 stimulates HES1 transcription (Homo sapiens)
HES1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH2 (Homo sapiens)
NOTCH2 intracellular domain regulates transcription (Homo sapiens)
NOTCH2 stimulates HES1 transcription (Homo sapiens)
HES1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Intracellular Domain Regulates Transcription (Homo sapiens)
HES1 gene expression is stimulated by NOTCH3 and STAT1 (Homo sapiens)
HES1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
NOTCH4 Intracellular Domain Regulates Transcription (Homo sapiens)
HES1 gene expression is stimulated by NOTCH4 (Homo sapiens)
HES1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14469 HES1
Gene Names
HES1, BHLHB39, HL, HRY
Chain
chain:1-280
Reference Genes
BioGPS Gene:3280 HES1
COSMIC (genes):HES1 HES1
CTD Gene:3280 HES1
dbSNP Gene:3280 HES1
ENSEMBL:ENSG00000114315 HES1
HGNC:5192 HES1
KEGG:hsa:3280 HES1
Monarch:3280 HES1
NCBI Gene:3280 HES1
OMIM:139605 HES1
UCSC:Q14469 HES1
Reference Transcript
RefSeq:NM_005524.3 HES1
Other Identifiers
11716550_at
11716551_s_at
11760345_a_at
11760346_at
11760347_x_at
16949759
203393_PM_at
203393_at
203394_PM_s_at
203394_s_at
203395_PM_s_at
203395_s_at
2658614
2658615
2658616
2658617
2658618
2658619
2658621
2658622
2658623
2658624
2658625
2658626
2658627
2658628
2658629
2658630
2658631
2658632
2658633
3280
37393_at
8084880
A_14_P128502
A_23_P17998
A_23_P6596
A_24_P938293
GE537019
GO:0000122
GO:0000785
GO:0000981
GO:0001217
GO:0001222
GO:0001227
GO:0001701
GO:0001709
GO:0001889
GO:0002085
GO:0002376
GO:0003143
GO:0003151
GO:0003266
GO:0003281
GO:0003310
GO:0003677
GO:0003682
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0006355
GO:0006357
GO:0007155
GO:0007163
GO:0007219
GO:0007224
GO:0007389
GO:0007399
GO:0008283
GO:0008284
GO:0008432
GO:0009952
GO:0010628
GO:0010629
GO:0010977
GO:0014070
GO:0016363
GO:0016477
GO:0021537
GO:0021555
GO:0021557
GO:0021558
GO:0021575
GO:0021861
GO:0021870
GO:0021915
GO:0021983
GO:0021984
GO:0023052
GO:0030154
GO:0030182
GO:0030324
GO:0030509
GO:0030513
GO:0030901
GO:0031016
GO:0032991
GO:0035019
GO:0035315
GO:0035881
GO:0035909
GO:0035910
GO:0042098
GO:0042102
GO:0042491
GO:0042531
GO:0042802
GO:0042803
GO:0042826
GO:0043226
GO:0043254
GO:0043279
GO:0043388
GO:0043398
GO:0043433
GO:0043565
GO:0044877
GO:0045165
GO:0045596
GO:0045598
GO:0045608
GO:0045664
GO:0045665
GO:0045687
GO:0045747
GO:0045892
GO:0045893
GO:0045944
GO:0045977
GO:0046331
GO:0046425
GO:0046427
GO:0046983
GO:0048469
GO:0048505
GO:0048538
GO:0048667
GO:0048711
GO:0048715
GO:0048844
GO:0048856
GO:0048870
GO:0050678
GO:0050767
GO:0050768
GO:0051087
GO:0060122
GO:0060164
GO:0060253
GO:0060412
GO:0060675
GO:0060716
GO:0061009
GO:0061101
GO:0061102
GO:0061106
GO:0061309
GO:0061626
GO:0061629
GO:0065003
GO:0070888
GO:0071347
GO:0071356
GO:0071398
GO:0071820
GO:0072012
GO:0072049
GO:0072050
GO:0072141
GO:0072282
GO:0090102
GO:0090162
GO:0090281
GO:0097066
GO:0097084
GO:0097150
GO:0140110
GO:1902870
GO:1905934
GO:1990090
GO:1990837
GO:2000227
GO:2000737
GO:2000974
GO:2000978
GO:2000981
HMNXSV003042963
Hs.250666.0.S1_3p_a_at
ILMN_1710284
L19314_at
PH_hs_0013273
TC03001071.hg
TC03002732.hg
g8400709_3p_a_at
Participates
as an output of
NOTCH1 PEST domain mutants stimulate HES1 transcription (Homo sapiens)
NOTCH2 stimulates HES1 transcription (Homo sapiens)
HES1 gene expression is stimulated by NOTCH3 and STAT1 (Homo sapiens)
HES1 gene expression is stimulated by NOTCH4 (Homo sapiens)
HES1 gene transcription is inhibited by RUNX3 (Homo sapiens)
NOTCH1 stimulates HES1 transcription (Homo sapiens)
as a component of
HES1:TLE [nucleoplasm] (Homo sapiens)
as an input of
HES1 binds TLE (Homo sapiens)
as a member of
HEY1,HEY2,HES1 [nucleoplasm] (Homo sapiens)
This entity regulates
Negatively
HNF6-dependent synthesis of NEUROG3 protein during morphogenesis
(Homo sapiens)
Cross References
RefSeq
NP_005515.1
ENSEMBL
ENST00000232424
,
ENSP00000232424
OpenTargets
ENSG00000114315
HPA
ENSG00000114315-HES1
PRO
Q14469
Pharos - Targets
Q14469
GlyGen
Q14469
PDB
7C4O
,
2MH3
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.544
4
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