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HNF6-dependent synthesis of HNF1B protein
Stable Identifier
R-HSA-210824
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Developmental Biology (Homo sapiens)
Regulation of beta-cell development (Homo sapiens)
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells (Homo sapiens)
HNF6-dependent synthesis of HNF1B protein (Homo sapiens)
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The HNF1B gene is transcribed, its mRNA is translated, and the protein products are transported to the nucleus. HNF1B transcription requires the activity of the HNF6 transcription factor. These events and interactions have not been studied directly in humans, but are inferred from corresponding ones worked out in the mouse.
Participants
Input
HNF1B gene [nucleoplasm]
(Homo sapiens)
Output
HNF1B [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells (Homo sapiens)
This event is regulated
Positively by
Regulator
ONECUT1 [nucleoplasm]
(Homo sapiens)
Inferred From
HNF6 positively regulates Hnf1b expression (Mus musculus)
Authored
Tello-Ruiz, MK (2008-05-24)
Ferrer, J (2008-05-24)
Reviewed
Jensen, J (2008-05-13)
Created
D'Eustachio, P (2008-01-17)
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