Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

Stable Identifier
R-HSA-210746
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
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Studies in mouse model systems indicate that the transcription factor neurogenin 3 plays a central role in the induction of endocrine differentiation in the developing pancreas (Servitja and Ferrer 2004; Chakrabarti and Mirmira 2003). In both mice and humans critical events in this induction process include the neurogenin 3 (NEUROG3)-dependent transcription of PAX4, NEUROD1, NKX2-2, and INSM1.

Literature References
PubMed ID Title Journal Year
15298336 Transcriptional networks controlling pancreatic development and beta cell function

Servitja, JM, Ferrer, J

Diabetologia 2004
12591178 Transcription factors direct the development and function of pancreatic beta cells

Chakrabarti, SK, Mirmira, RG

Trends Endocrinol Metab 2003
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Events
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as an event of
Event Information
Go Biological Process
endocrine pancreas development (0031018)
Authored
Tello-Ruiz, MK  (2008-05-24)
Ferrer, J  (2008-05-24)
Reviewed
Jensen, J  (2008-05-13)
Created
D'Eustachio, P  (2008-01-16)
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