Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

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R-HSA-210746
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Homo sapiens
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Studies in mouse model systems indicate that the transcription factor neurogenin 3 plays a central role in the induction of endocrine differentiation in the developing pancreas (Servitja and Ferrer 2004; Chakrabarti and Mirmira 2003). In both mice and humans critical events in this induction process include the neurogenin 3 (NEUROG3)-dependent transcription of PAX4, NEUROD1, NKX2-2, and INSM1.

Literature References
PubMed ID Title Journal Year
12591178 Transcription factors direct the development and function of pancreatic beta cells

Chakrabarti, SK, Mirmira, RG

Trends Endocrinol Metab 2003
15298336 Transcriptional networks controlling pancreatic development and beta cell function

Servitja, JM, Ferrer, J

Diabetologia 2004
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