WWTR1:SMAD translocates to the nucleus

Stable Identifier
R-HSA-2106579
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
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WWTR1:SMAD translocates to the nucleus
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TGF-beta-dependent nuclear accumulation of SMAD2/3 and SMAD4 is mediated by WWTR1 (TAZ). WWTR1 does not affect phosphorylation of SMAD2/3 or the formation of SMAD2/3:SMAD4 trimers.

Literature References
PubMed ID Title Journal Year
18568018 TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

Varelas, X, Sakuma, R, Samavarchi-Tehrani, P, Peerani, R, Rao, BM, Dembowy, J, Yaffe, MB, Zandstra, PW, Wrana, JL

Nat Cell Biol 2008
Participants
Input
Output
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Orthologous Events
WWTR1:SMAD translocates to the nucleus (Caenorhabditis elegans)
WWTR1:SMAD translocates to the nucleus (Canis familiaris)
WWTR1:SMAD translocates to the nucleus (Danio rerio)
WWTR1:SMAD translocates to the nucleus (Mus musculus)
WWTR1:SMAD translocates to the nucleus (Rattus norvegicus)
WWTR1:SMAD translocates to the nucleus (Sus scrofa)
WWTR1:SMAD translocates to the nucleus (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-02-11)
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