WWTR1:SMAD translocates to the nucleus

Stable Identifier
R-HSA-2106579
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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WWTR1:SMAD translocates to the nucleus
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TGF-beta-dependent nuclear accumulation of SMAD2/3 and SMAD4 is mediated by WWTR1 (TAZ). WWTR1 does not affect phosphorylation of SMAD2/3 or the formation of SMAD2/3:SMAD4 trimers.
Literature References
PubMed ID Title Journal Year
18568018 TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

Wrana, JL, Peerani, R, Rao, BM, Samavarchi-Tehrani, P, Sakuma, R, Zandstra, PW, Varelas, X, Yaffe, MB, Dembowy, J

Nat Cell Biol 2008
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Orthologous Events
WWTR1:SMAD translocates to the nucleus (Bos taurus)
WWTR1:SMAD translocates to the nucleus (Caenorhabditis elegans)
WWTR1:SMAD translocates to the nucleus (Canis familiaris)
WWTR1:SMAD translocates to the nucleus (Danio rerio)
WWTR1:SMAD translocates to the nucleus (Drosophila melanogaster)
WWTR1:SMAD translocates to the nucleus (Gallus gallus)
WWTR1:SMAD translocates to the nucleus (Mus musculus)
WWTR1:SMAD translocates to the nucleus (Rattus norvegicus)
WWTR1:SMAD translocates to the nucleus (Sus scrofa)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Contreras, O  (2022-05-02)
Created
Orlic-Milacic, M  (2012-02-11)
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