Reactome | p-JAK2 [cytosol]

p-JAK2 [cytosol]

Stable Identifier

R-HSA-210621

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phospho JAK2

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O60674 JAK2

Gene Names

JAK2

Chain

chain:1-1132

Reference Genes

BioGPS Gene:3717 JAK2

COSMIC (genes):JAK2 JAK2

CTD Gene:3717 JAK2

dbSNP Gene:3717 JAK2

ENSEMBL:ENSG00000096968 JAK2

HGNC:6192 JAK2

KEGG:hsa:3717 JAK2

Monarch:3717 JAK2

NCBI Gene:3717 JAK2

OMIM:147796 JAK2

UCSC:O60674 JAK2

Reference Transcript

Other Identifiers

11733372_a_at

11733373_at

11756857_a_at

17083319

205841_PM_at

205841_at

205842_PM_s_at

205842_s_at

3160892

3160894

3160896

3160897

3160898

3160899

3160904

3160905

3160906

3160907

3160931

3160932

3160933

3160935

3160936

3160937

3160941

3160944

3160946

3160947

3160949

3160950

3160951

3160953

3160954

3160956

3160957

3160958

3160960

3160962

3160963

3161009

3161012

3161013

3161014

3161015

3161016

3161017

3161019

3161020

3161022

3717

37468_at

78910_i_at

78912_r_at

8154178

A_14_P105543

A_14_P127099

A_14_P136058

A_23_P123608

A_33_P3878772

GE79112

GO:0000791

GO:0001774

GO:0002250

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005131

GO:0005143

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005901

GO:0005925

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006366

GO:0006468

GO:0006915

GO:0006919

GO:0006955

GO:0006979

GO:0007165

GO:0007167

GO:0007186

GO:0007204

GO:0007259

GO:0007260

GO:0007498

GO:0008284

GO:0008285

GO:0008631

GO:0009755

GO:0009898

GO:0010572

GO:0010667

GO:0010811

GO:0012501

GO:0012505

GO:0014070

GO:0014075

GO:0016020

GO:0016740

GO:0018108

GO:0019221

GO:0019897

GO:0019901

GO:0020037

GO:0022408

GO:0030041

GO:0030099

GO:0030154

GO:0030155

GO:0030218

GO:0030335

GO:0030526

GO:0031103

GO:0031234

GO:0031702

GO:0031904

GO:0031959

GO:0032024

GO:0032496

GO:0032729

GO:0032731

GO:0032740

GO:0032760

GO:0032819

GO:0033130

GO:0033194

GO:0033209

GO:0034050

GO:0034612

GO:0035166

GO:0035401

GO:0035556

GO:0035722

GO:0036016

GO:0038043

GO:0038065

GO:0038155

GO:0038156

GO:0038157

GO:0038162

GO:0042022

GO:0042102

GO:0042169

GO:0042307

GO:0042393

GO:0042531

GO:0042802

GO:0042976

GO:0042981

GO:0043065

GO:0043066

GO:0043226

GO:0043392

GO:0043410

GO:0043524

GO:0043548

GO:0043560

GO:0043687

GO:0045087

GO:0045121

GO:0045348

GO:0045428

GO:0045429

GO:0045597

GO:0045944

GO:0046425

GO:0046427

GO:0046677

GO:0046777

GO:0046872

GO:0048008

GO:0048856

GO:0050727

GO:0050804

GO:0050867

GO:0051142

GO:0051239

GO:0051428

GO:0051770

GO:0051897

GO:0060333

GO:0060391

GO:0060396

GO:0060397

GO:0060399

GO:0061180

GO:0065003

GO:0070102

GO:0070665

GO:0070671

GO:0070757

GO:0071222

GO:0071549

GO:0072536

GO:0097191

GO:0097296

GO:0098542

GO:0098586

GO:0098794

GO:0098978

GO:0120162

GO:0140096

GO:1901731

GO:1902728

GO:1904037

GO:1904707

GO:1905539

GO:2000273

GO:2000318

GO:2001235

HMNXSV003006385

ILMN_1683178

PH_hs_0025325

TC09000035.hg

g13325062_3p_at

g3236321_3p_a_at

Participates

as a component of

as a member of

Other forms of this molecule

JAK2 [cytosol]

p-Y1007-JAK2 [cytosol]

p-12Y-JAK2 [cytosol]

JAK2 [endosome lumen]

JAK2 V617F [nucleoplasm]

p-Y813-JAK2 [cytosol]

p-Y1007,Y1008-JAK2 [cytosol]

Inferred To

phospho-p-JAK2 [cytosol] (Bos taurus)

phospho-p-JAK2 [cytosol] (Canis familiaris)

phospho-p-JAK2 [cytosol] (Drosophila melanogaster)

phospho-p-JAK2 [cytosol] (Gallus gallus)

phospho-p-JAK2 [cytosol] (Mus musculus)

phospho-p-JAK2 [cytosol] (Rattus norvegicus)

phospho-p-JAK2 [cytosol] (Sus scrofa)

phospho-p-JAK2 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_004963.1, NP_001309133.1, NP_001309125.1, NP_001309124.1, NP_001309123.1

ZINC - World Drugs

JAK2_HUMAN

Guide to Pharmacology - Targets

2048

OpenTargets

ENSG00000096968

ENSEMBL

ENSP00000371067, ENST00000381652

ZINC - FDA approved

JAK2_HUMAN

ZINC - Substances

JAK2_HUMAN

ZINC - Biogenic

JAK2_HUMAN

ZINC target

O60674

PRO

O60674

GlyGen

O60674

PDB

7F7W, 6OCC, 6BBV, 4ZIM, 4GMY, 8BA3, 3KCK, 6VNE, 6M9H, 5TQ5, 6TPD, 6AAJ, 5USZ, 4AQC, 8CZ9, 7LL4, 5UT3, 8BA2, 5L3A, 8BPV, 7Q7K, 7Q7W, 6WTP, 6VN8, 7Q7I, 5TQ8, 6VNK, 5WIN, 3IOK, 7REE, 5HEZ, 6XJK, 4FVR, 5CF4, 8BAK, 8B8U, 4YTF, 8B9H, 5AEP, 2W1I, 3LPB, 7T1T, 4BBE, 4F08, 5CF8, 6VNL, 7JYO, 6VSN, 2XA4, 6VS3, 4JIA, 4IVA, 5USY, 8BX9, 4E6D, 7LL5, 5WIL, 8BXH, 7Q7L, 8BPW, 6BRW, 6VNJ, 8F88, 6E2Q, 6WTN, 3ZMM, 8B8N, 4D1S, 4YTI, 4C61, 8BAB, 6OAV, 4GFM, 3IO7, 3RVG, 3UGC, 3JY9, 8EYA, 8EX2, 4E6Q, 5WEV, 8G6Z, 5UT6, 3Q32, 3FUP, 5UT5, 6VNM, 8BA4, 5TQ4, 7RN6, 8C08, 5TQ3, 8C09, 8BX6, 4D0W, 3E62, 5UT2, 6VNG, 3KRR, 4Z32, 4P7E, 3E64, 5UT0, 6VNI, 8G8O, 4F09, 8G8X, 5WIM, 6VNC, 7TEU, 5TQ7, 6OBB, 4FVP, 3TJC, 4YTC, 4HGE, 5CF5, 6D2I, 5CF6, 8EX0, 5I4N, 5UT4, 4BBF, 8EXK, 6BS0, 7JYQ, 6G3C, 2B7A, 6OBL, 4E4M, 4JI9, 8C0A, 6BSS, 3E63, 6WTQ, 6VNF, 4D0X, 5WIJ, 6E2P, 6WTO, 6VNH, 8BXC, 6DRW, 5WIK, 5UT1, 6X8E, 7UYW, 6VNB, 5TQ6, 3TJD, 4YTH, 6VGL, 8BM2, 4C62, 4FVQ, 8B99, 8EX1, 8EYB, 6OBF, 8B9E, 7T0P

ZINC - Investigational

JAK2_HUMAN

HPA

ENSG00000096968-JAK2

Pharos - Targets

O60674

Orphanet

JAK2

ZINC - Predictions - Purchasable

JAK2_HUMAN

HMDB Protein

HMDBP01194

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18031 PTPN1	2	PTPN1 [endosome membrane] (R-HSA-9815895) PTPN1 [cytosol] (R-HSA-210625)	0.819	5
UniProt:O60674 JAK2	8	JAK2 [cytosol] (R-HSA-210620) p-Y1007-JAK2 [cytosol] (R-HSA-873799) p-12Y-JAK2 [cytosol] (R-HSA-2586516) JAK2 [endosome lumen] (R-HSA-2002372) JAK2 V617F [nucleoplasm] (R-HSA-5211269) p-Y813-JAK2 [cytosol] (R-HSA-997248) p-JAK2 [cytosol] (R-HSA-210621) p-Y1007,Y1008-JAK2 [cytosol] (R-HSA-9005327)	0.623	7
UniProt:P32927 CSF2RB	6	p-Y593,Y628-CSF2RB [plasma membrane] (R-HSA-912312) CSF2RB [plasma membrane] (R-HSA-879960) p-S585-CSF2RB [plasma membrane] (R-HSA-914170) p-Y593-CSF2RB [plasma membrane] (R-HSA-914092) CSF2RB R211Efs*54 [plasma membrane] (R-HSA-5688863) CSF2RB S271L [plasma membrane] (R-HSA-5688879)	0.564	4
UniProt:Q9NZI7 UBIP1			0.527	2
UniProt:Q9NRF2 SH2B1	1	SH2B1 [cytosol] (R-HSA-997253)	0.527	2
UniProt:Q9JHI9	1	SLC40A1 [plasma membrane] (R-MMU-442390)	0.524	3
UniProt:P40238 MPL	1	MPL [plasma membrane] (R-HSA-443938)	0.518	6
UniProt:Q01344 IL5RA	1	IL5RA [plasma membrane] (R-HSA-450072)	0.499	2
UniProt:P23458 JAK1	6	p-Y-JAK1 [cytosol] (R-HSA-451921) JAK1 [cytosol] (R-HSA-451898) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) p-JAK1 [cytosol] (R-HSA-8950711) JAK1 [endosome] (R-HSA-8983168) p-Y1034,Y1035-JAK1 [cytosol] (R-HSA-9005335)	0.463	4

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