Reactome | CACNG4 [plasma membrane]

CACNG4 [plasma membrane]

Stable Identifier

R-HSA-210417

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Gamma 4 subunit of VGCC, stargazin

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- LGI-ADAM interactions (Homo sapiens)
  - LGI1 binds ADAM22 and ADAM23 (Homo sapiens)
    - ADAM22:LGI1 dimer:ADAM23 [plasma membrane] (Homo sapiens)
      - ADAM22:PSD-95:stargazin [plasma membrane] (Homo sapiens)
        
        Gamma subunit of VGCC (Stargazin) [plasma membrane] (Homo sapiens)
        
        CACNG4 [plasma membrane] (Homo sapiens)
    - ADAM22:PSD-95:stargazin [plasma membrane] (Homo sapiens)
      - Gamma subunit of VGCC (Stargazin) [plasma membrane] (Homo sapiens)
        
        CACNG4 [plasma membrane] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
      - Trafficking of AMPA receptors (Homo sapiens)
        
        Trafficking of GluR1-containing AMPA receptors (Homo sapiens)
        
        TARP-PSD95-Mdm2 [plasma membrane] (Homo sapiens)
        
        Gamma subunit of VGCC (Stargazin) [plasma membrane] (Homo sapiens)
        
        CACNG4 [plasma membrane] (Homo sapiens)
  - Presynaptic depolarization and calcium channel opening (Homo sapiens)
    - Ca2+ influx through voltage gated Ca2+ channels (Homo sapiens)
      - Voltage Gated Ca2+ Channel [plasma membrane] (Homo sapiens)
        
        calcium channel multimer of R type VGCC [plasma membrane] (Homo sapiens)
        
        CACNG4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UBN1 CACNG4

Gene Names

CACNG4

Chain

chain:1-327

Reference Genes

BioGPS Gene:27092 CACNG4

COSMIC (genes):CACNG4 CACNG4

CTD Gene:27092 CACNG4

dbSNP Gene:27092 CACNG4

ENSEMBL:ENSG00000075461 CACNG4

ENSEMBL_homo_sapiens_GENE:ENSG00000075461.6 CACNG4

HGNC:1408 CACNG4

KEGG Gene (Homo sapiens):27092 CACNG4

Monarch:27092 CACNG4

NCBI Gene:27092 CACNG4

OMIM:606404 CACNG4

UCSC:Q9UBN1 CACNG4

Reference Transcript

RefSeq:NM_014405.3 CACNG4

Other Identifiers

11722468_at

16837172

221585_PM_at

221585_at

231737_PM_at

231737_at

27092

3732093

3732094

3732095

3732118

3732128

3732136

3732137

3732138

3732139

3732140

3732142

4860276C_3p_s_at

62987_3p_r_at

62987_PM_r_at

62987_r_at

77288_at

8009334

A_24_P70303

A_33_P3341299

GE61635

GO:0005215

GO:0005245

GO:0005246

GO:0005262

GO:0005886

GO:0005891

GO:0006811

GO:0006816

GO:0006886

GO:0009986

GO:0016020

GO:0016192

GO:0016247

GO:0019226

GO:0023052

GO:0030666

GO:0031410

GO:0032281

GO:0034220

GO:0034702

GO:0035255

GO:0036477

GO:0042220

GO:0043226

GO:0044297

GO:0050877

GO:0051968

GO:0055085

GO:0070588

GO:0098772

GO:0098839

GO:0098943

GO:0098970

GO:0098978

GO:0099590

GO:1990454

GO:2000311

HMNXSV003017378

Hs.331904.0.S1_3p_at

ILMN_1702149

PH_hs_0016270

TC17000790.hg

g13325399_3p_s_at

Participates

as a member of

as a component of

calcium channel multimer of R type VGCC [plasma membrane] (Homo sapiens)

Other forms of this molecule

CACNG4 [endocytic vesicle membrane]

Inferred To

Cacng4 [plasma membrane] (Mus musculus)

Cacng4 [plasma membrane] (Rattus norvegicus)

stg-2 [plasma membrane] (Caenorhabditis elegans)

cacng4 [plasma membrane] (Xenopus tropicalis)

CACNG4 [plasma membrane] (Bos taurus)

CACNG4 [plasma membrane] (Canis familiaris)

CACNG4 [plasma membrane] (Gallus gallus)

CACNG4 [plasma membrane] (Sus scrofa)

Homologues of CACNG4 [plasma membrane] (Caenorhabditis elegans)

stg-1 [plasma membrane] (Caenorhabditis elegans)

stg1 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_055220.1

OpenTargets

ENSG00000075461

HPA

ENSG00000075461-CACNG4

GeneCards

Q9UBN1

Ensembl

ENST00000262138, ENSP00000262138, ENSG00000075461

PRO

Q9UBN1

Pharos - Targets

Q9UBN1

HMDB Protein

HMDBP07564