Interaction of DAP12 and KIR2DS2

Stable Identifier
R-HSA-210309
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Interaction of DAP12 and KIR2DS2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Killer cell immunoglobulin-like two-domain short-tail receptor 2 (KIR2DS2) is an activating KIR receptor invariably expressed on the cell surface of NK cells and subsets of T cells. The ligand specificity of KIR2DS2 is unknown; it does not bind the HLA-Cw3 molecules recognised by the inhibitory receptor KIR2DL2, despite 99% extracellular amino acid identity (Saulquin et al. 2003). In the presence of DAP12, cross-linking of KIR2DS2 with monoclonal antibody leads to phosphorylation of JNK and ERK and activation of both cytotoxicity and IFN-production.
Literature References
PubMed ID Title Journal Year
12668644 Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j)

Vivier, E, Gastinel, LN, Saulquin, X

J Exp Med 2003
Participants
Input
Output
Participates
as an event of
Orthologous Events
Interaction of DAP12 and KIR2DS2 (Mus musculus)
Interaction of DAP12 and KIR2DS2 (Rattus norvegicus)
Interaction of DAP12 and KIR2DS2 (Sus scrofa)
Authored
Garapati, P V  (2012-05-25)
Reviewed
Lanier, LL  (2012-08-09)
Created
Garapati, P V  (2008-01-10)
Cite Us!