Interaction of DAP12 and KIR3DS1

Stable Identifier
R-HSA-210298
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Killer cell immunoglobulin-like three-domain short-tail receptor 1 (KIR3DS1) is a member of the KIR family expressed on peripheral natural killer (NK) cells and implicated in protection against HIV (Carr et al. 2007, Pascal et al. 2007). The physiological ligand for KIR3DS1 is not clearly determined but it has been suggested to bind HLA-B Bw4-80I on HIV-1-infected target cells (Qi et al. 2006). KIR3DS1 associates with DAP12 and this association enhances its cell surface expression. Crosslinking KIR3DS1 with a monoclonal antibody stimulates NK cell-mediated cytolysis and IFN-gamma production (Carr et al. 2007).

Literature References
PubMed ID Title Journal Year
17641029 Detection of KIR3DS1 on the cell surface of peripheral blood NK cells facilitates identification of a novel null allele and assessment of KIR3DS1 expression during HIV-1 infection

Pascal, V, Yamada, E, Martin, MP, Alter, G, Altfeld, M, Metcalf, JA, Baseler, MW, Adelsberger, JW, Carrington, M, Anderson, SK, McVicar, DW

J Immunol 2007
16933987 KIR/HLA pleiotropism: protection against both HIV and opportunistic infections

Qi, Y, Martin, MP, Gao, X, Jacobson, L, Goedert, JJ, Buchbinder, S, Kirk, GD, O'Brien, SJ, Trowsdale, J, Carrington, M

PLoS Pathog 2006
17202323 Cutting Edge: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation

Carr, WH, Rosen, DB, Arase, H, Nixon, DF, Michaelsson, J, Lanier, LL

J Immunol 2007
Participants
Participant Of
Authored
Reviewed
Created