Killer cell immunoglobulin-like three-domain short-tail receptor 1 (KIR3DS1) is a member of the KIR family expressed on peripheral natural killer (NK) cells and implicated in protection against HIV (Carr et al. 2007, Pascal et al. 2007). The physiological ligand for KIR3DS1 is not clearly determined but it has been suggested to bind HLA-B Bw4-80I on HIV-1-infected target cells (Qi et al. 2006). KIR3DS1 associates with DAP12 and this association enhances its cell surface expression. Crosslinking KIR3DS1 with a monoclonal antibody stimulates NK cell-mediated cytolysis and IFN-gamma production (Carr et al. 2007).
Gao, X, O'Brien, SJ, Trowsdale, J, Martin, MP, Buchbinder, S, Carrington, M, Goedert, JJ, Jacobson, L, Kirk, GD, Qi, Y
Baseler, MW, Anderson, SK, Alter, G, Martin, MP, Metcalf, JA, Altfeld, M, Yamada, E, Pascal, V, Carrington, M, McVicar, DW, Adelsberger, JW
Lanier, LL, Rosen, DB, Nixon, DF, Michaelsson, J, Arase, H, Carr, WH
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