Interaction of DAP12 and KIR3DS1

Stable Identifier
Reaction [binding]
Homo sapiens
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Killer cell immunoglobulin-like three-domain short-tail receptor 1 (KIR3DS1) is a member of the KIR family expressed on peripheral natural killer (NK) cells and implicated in protection against HIV (Carr et al. 2007, Pascal et al. 2007). The physiological ligand for KIR3DS1 is not clearly determined but it has been suggested to bind HLA-B Bw4-80I on HIV-1-infected target cells (Qi et al. 2006). KIR3DS1 associates with DAP12 and this association enhances its cell surface expression. Crosslinking KIR3DS1 with a monoclonal antibody stimulates NK cell-mediated cytolysis and IFN-gamma production (Carr et al. 2007).
Literature References
PubMed ID Title Journal Year
16933987 KIR/HLA pleiotropism: protection against both HIV and opportunistic infections

Gao, X, O'Brien, SJ, Trowsdale, J, Martin, MP, Buchbinder, S, Carrington, M, Goedert, JJ, Jacobson, L, Kirk, GD, Qi, Y

PLoS Pathog 2006
17641029 Detection of KIR3DS1 on the cell surface of peripheral blood NK cells facilitates identification of a novel null allele and assessment of KIR3DS1 expression during HIV-1 infection

Baseler, MW, Anderson, SK, Alter, G, Martin, MP, Metcalf, JA, Altfeld, M, Yamada, E, Pascal, V, Carrington, M, McVicar, DW, Adelsberger, JW

J Immunol 2007
17202323 Cutting Edge: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation

Lanier, LL, Rosen, DB, Nixon, DF, Michaelsson, J, Arase, H, Carr, WH

J Immunol 2007
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