Reactome | Interaction of PECAM-1 and SHIP

Interaction of PECAM-1 and SHIP

Stable Identifier

R-HSA-210290

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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PECAM/CD31 is a member of the immunoglobulin superfamily (IgSF) and has been implicated to mediate the adhesion and trans-endothelial migration of T-lymphocytes into the vascular wall, T cell activation and angiogenesis. It has six Ig homology domains within its extracellularly and an ITIM motif within its cytoplasmic region.
PECAM-mediated adhesion is complex, because it is capable of binding both to itself (homophilic adhesion) and to non-PECAM ligands (heterophilic adhesion). The trans-homophilic interaction between the two PECAM-1 molecules is mediated by their NH2-terminal membrane distal Ig homology domains 1 and 2 plus the proper spacing formed by the six Ig-homology domains.

Literature References

PubMed ID	Title	Journal	Year
10350061	Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31 Pumphrey, NJ, Buckley, CD, Douglas, MR, Taylor, V, Lord, JM, Salmon, M, Bird, IN, Young, SP, Wakelam, MJ, Bradfield, PF, Freeman, S	FEBS Lett	1999