Interaction of PECAM-1 and PLC gamma1

Stable Identifier
R-HSA-210283
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Like SHP-1 and SHP-2, PLC-gamma 1 also interacts with PECAM-1. PLC-gamma 1 binds with both the tyrosine residues (Y663 and Y686). Unlike the N-SH2 domain, the C-SH2 domain on PLC-gamma 1 can only bind phosphotyrosine 663. The engagement of PECAM-1 with PLC-gamma 1 may lead to PLC-gamma 1 activation and subsequent calcium influx.

Literature References
PubMed ID Title Journal Year
10350061 Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31

Pumphrey, NJ, Taylor, V, Freeman, S, Douglas, MR, Bradfield, PF, Young, SP, Lord, JM, Wakelam, MJ, Bird, IN, Salmon, M, Buckley, CD

FEBS Lett 1999
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created