SIRP beta binds TYROBP

Stable Identifier
R-HSA-210274
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

SIRP beta (SIRPB, CD172b) is expressed mainly on myeloid cells and has a very short cytoplasmic region of only six amino acids, lacking the signaling motifs required for association with phosphatases that are found in SIRPA. Instead, SIRPB associates with a dimeric protein TYROBP (DAP12) to transmit activating signals via its ITAM motif. A positively charged amino acid in the transmembrane domain of TYROBP associates with a basic amino acid in the transmembrane region of SIRPB.

Literature References
PubMed ID Title Journal Year
10940905 Association of signal-regulatory proteins beta with KARAP/DAP-12

Tomasello, E, Cant, C, Buhring, HJ, Vely, F, Andre, P, Seiffert, M, Ullrich, A, Vivier, E

Eur J Immunol 2000
10604985 Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells

Dietrich, J, Cella, M, Seiffert, M, Buhring, HJ, Colonna, M

J Immunol 2000
Participants
Participant Of
Orthologous Events
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