Reactome | SIRP beta binds TYROBP

SIRP beta binds TYROBP

Stable Identifier

R-HSA-210274

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SIRP beta (SIRPB, CD172b) is expressed mainly on myeloid cells and has a very short cytoplasmic region of only six amino acids, lacking the signaling motifs required for association with phosphatases that are found in SIRPA. Instead, SIRPB associates with a dimeric protein TYROBP (DAP12) to transmit activating signals via its ITAM motif. A positively charged amino acid in the transmembrane domain of TYROBP associates with a basic amino acid in the transmembrane region of SIRPB.

Literature References

PubMed ID	Title	Journal	Year
10604985	Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells Buhring, HJ, Colonna, M, Dietrich, J, Seiffert, M, Cella, M	J Immunol	2000
10940905	Association of signal-regulatory proteins beta with KARAP/DAP-12 Vivier, E, Cant, C, Vely, F, Ullrich, A, Buhring, HJ, Andre, P, Tomasello, E, Seiffert, M	Eur J Immunol	2000