Reactome | Interaction of DAP12 and MDL-1

Interaction of DAP12 and MDL-1

Stable Identifier

R-HSA-210271

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Myeloid DAP12-associating lectin (MDL)-1, also designated CLEC5A, is a type II transmembrane protein belonging to the C-type lectin superfamily and expressed exclusively in monocytes and macrophages. MDL-1 contains a charged residue in the transmembrane region and this enables it to pair with DAP12 dimers. MDL-1's natural mammalian ligand is unknown, but MDL-1 is a receptor for Dengue virus CLEC5A is critical for dengue-virus-induced lethal disease (Chen et al 2008). Engagement with DAP12 has been shown to regulate osteoclastogenesis and myeloid cell-associated inflammatory responses (Bakker et al. 1999, Aoki et al. 2009, Inui et al 2009, Joyce-Shaikh et al. 2010, Cheung et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
15884055	KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions Vivier, E, Tomasello, E	Eur J Immunol	2005
10449773	Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells Lanier, LL, Phillips, JH, Baker, E, Bakker, AB, Sutherland, GR	Proc Natl Acad Sci U S A	1999